Clinical Case: ALS (Lou Gehrig's Disease) — Complete Symptom Reversal with Oral CDS and IV CDI by Dr. Gustavo de León

Background

Dr. Gustavo de León, a physician from Las Palmas de Gran Canaria, Spain, published a detailed clinical case report in July 2015 documenting his own self-experiment with CDS (chlorine dioxide solution) and CDI (chlorine dioxide infusion) for the treatment of Amyotrophic Lateral Sclerosis (ALS).

ALS (also known as Lou Gehrig's disease) is a progressive neurodegenerative disease affecting nerve cells in the brain and spinal cord, causing loss of muscle function and paralysis. It is typically fatal within 5 years due to respiratory failure.

Protocol Applied

• • Phase 1 — Oral CDS (August 2014 — March 2015, ~5 months):**

The doctor began with oral CDS, starting at 1ml per liter of water and gradually increasing:

• Week 1: 1ml CDS/liter, 8 doses/day (hourly)
• Week 2: 1.5ml CDS/liter, 10 doses/day
• Week 3: 1.5ml CDS/liter, 12 doses/day
• Week 4: 2ml CDS/liter, 12 doses/day
• Week 5: 2.5ml CDS/liter, 12 doses/day
• Week 6-8: 2.5-3ml CDS/liter, 12 doses/day
• Month 3-4: 3ml CDS/liter, 12 doses/day

• • Phase 2 — IV CDI (March 2015 — April 2015):**

Due to continued improvement, the doctor added intravenous CDI:

• Started with 10ml CDI in 250ml saline + 10ml DMSO, 60-minute infusion
• Gradually increased to 40ml CDI in 500ml saline, 60-minute infusion
• DMSO used for pH adjustment (1.8ml DMSO per 3ml CDS = pH 7.3)
• Discovered that adding a drop of sodium chlorite to the saline was the best pH correction method
• Used T-shaped perfusion system to avoid phlebitis
• Larger vein calibers (20-22 gauge catheter) reduced pain

• • Phase 3 — Maintenance (May 2015 onwards):**

• Intravenous CDI every 7 days maximum
• Daily oral CDS as maintenance (3ml/hour, 12 doses/day)
• Discovered that IV effect lasts 2-3 days

Results — Symptom Timeline

• • Week 1 (August 29, 2014):** Occasional headaches, diarrhea without colic.

• • Week 2 (September 5, 2014):** Diarrhea disappeared. Night cramps disappeared. Appetite increased.

• • Week 3 (September 12, 2014):** Indigestion, acidity, bread intolerance disappeared. Bad halitosis disappeared.

• • Week 4 (September 19, 2014):** Speech improved daily. Muscle strength increased. Dysphagia, dyspnea, and sialorrhea disappeared. Mood improved. Slept 9 hours flat. Tinnitus disappeared. Regular bowel movements.

• • Week 5 (September 26, 2014):** Increased strength. Hair loss stopped.

• • Week 6 (October 3, 2014):** Increased muscle strength and mass.

• • Week 7 (October 10, 2014):** Increased strength — more physiotherapy sessions possible.

• • Month 4 (December 2014):** Switched from CDS to CDH (chlorine dioxide gas) for 1 month — no improvement, some regression noted.

• • February-March 2015:** Returned to CDS. Noted improvement, though lacking strength. Blood pressure dropped (both diastolic and systolic).

• • March 2015 (IV CDI started):** Fasciculations, hyperreflexia, and spasticity (the ALS "triad") disappeared rapidly.

• • April 2015:** Complete absence of fasciculations, hyperreflexia, and spasticity. Muscle volume increased in arms. Fatigue decreased. No emotional lability. No dysphagia. No sialorrhea (only nocturnal). Slept flat without assisted breathing.

• • May 2015:** Clinical tests showed improvement: spirometry, blood gas analysis, and pulse oximetry all improved.

• • June-July 2015:** No regression. Quick recovery after exercise. Maintained appetite — could eat and drink anything without thickeners. Slept flat without assisted breathing. No emotional lability, no spasticity, no hyperreflexia. No fasciculations except occasional mild ones after exercise.

• • Critical Discovery:** When Dr. de León stopped all treatment (both oral and IV) for several days, ALS symptoms returned. Upon resuming treatment, improvement was immediate. This demonstrated the direct effect of CDS/CDI on ALS symptoms.

Clinical Conclusions

The doctor concluded that:

1. **Oral CDS** produces noticeable improvement but **IV CDI is significantly more effective** 2. The effect of a 40ml IV infusion lasts approximately 2-3 days 3. The ALS "triad" (fasciculations, hyperreflexia, spasticity) disappears rapidly with IV CDI 4. Symptom return after treatment interruption and immediate improvement upon resumption demonstrates the drug's direct effect 5. Pain in infusion veins is a significant challenge requiring pH adjustment and larger vein calibers 6. The best protocol appears to be: initial oral phase → intensive IV phase → oral maintenance with periodic IV boosters 7. Treatment interruptions should be brief and guided by early symptom signals

Proposed Protocol

1. Start with oral CDS for several weeks 2. Progress to intravenous CDI (increasing dose to maximum, then tapering) 3. Continue with oral maintenance doses 4. Intermittent rest periods of a few days, guided by early symptom signals 5. Maintain constant rehabilitation

Mechanism of Action

While previous studies with sodium chlorite suggest the therapeutic effect resides in its ability to affect macrophages and balance the immune response involved in the inflammatory process, Dr. de León attributes the benefits of CDS to a possible oxidation of glutamate and aberrant proteins at the neuronal level, reducing neurotoxicity (excitotoxicity).

Acknowledgments

The author acknowledges Dr. Gustavo de León for his remarkable courage and dedication as a physician-researcher who experimented on himself, providing all clinical data collected from personal experience.

Source

Clinical case report by Dr. Gustavo de León, Las Palmas de Gran Canaria, Spain (July 2015). Full report available as PDF attachment.