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# '''Clarifying the science of chlorine dioxide solution (CDS): Addressing misinformation and establishing evidence for medical use.''' Kalcker, A. L. (2025). ''International Journal of Multidisciplinary Research and Analysis'', '''8'''(3), 54–62. This review addresses misinformation about CDS, presenting evidence for its potential medical use in treating infections. [https://ijmra.in/v8i3/54.php]</ref> <ref>
# '''Clarifying the science of chlorine dioxide solution (CDS): Addressing misinformation and establishing evidence for medical use.''' Kalcker, A. L. (2025). ''International Journal of Multidisciplinary Research and Analysis'', '''8'''(3), 54–62. This review addresses misinformation about CDS, presenting evidence for its potential medical use in treating infections. [https://ijmra.in/v8i3/54.php]</ref> <ref>
# '''An international consensus report on SARS-CoV-2, COVID-19, and the immune system: An orthomolecular view.''' International Society for Orthomolecular Medicine. (n.d.). ''Journal of Orthomolecular Medicine'', '''35'''(1). This report discusses orthomolecular approaches, including CDS, for COVID-19 management. [https://isom.ca/article/an-international-consensus-report-on-sars-cov-2-covid-19-and-the-immune-system-an-orthomolecular-view/]</ref> <ref>
# '''An international consensus report on SARS-CoV-2, COVID-19, and the immune system: An orthomolecular view.''' Author(s): Michael J Gonzalez<sup>1,3‚4</sup>; Jorge R Miranda-Massari<sup>2‚4</sup>; Peter A McCullough<sup>5</sup>; Paul E Marik<sup>6</sup>; Pierre Kory<sup>7</sup>; Ryan Cole<sup>8</sup>; Geert Vanden Bossche<sup>9</sup>; Charles Simone<sup>10</sup>; Manuel Aparicio Alonso<sup>11</sup>; Ernesto Prieto Gratacos<sup>12</sup>; Atsuo Yanagisawa<sup>13</sup>; Richard Cheng<sup>14</sup>; Eduardo Insignares-Carrione<sup>15</sup>; Zhiyong Peng¹<sup>6</sup>; Robert J Rowen¹<sup>7</sup>; Teresa B Su¹<sup>7</sup>; Frank Shallenberger<sup>18</sup>; David Brownstein<sup>19</sup>; Thomas Levy<sup>20</sup>; Jorge L Cubrias<sup>21</sup>; Arturo O’Byrne Navia<sup>22</sup>; Arturo O’Byrne De Valdenebro<sup>23</sup>; Alex Vasquez<sup>24</sup>; Ron Hunninghake<sup>25</sup>; Andrew Saul<sup>26</sup>; Hugo Galindo<sup>27</sup>; Andreas L Kalcker<sup>28</sup>; Mayca Gonzalez<sup>29</sup>; Luis A Bonilla-Soto<sup>30</sup>; María  Carrascal<sup>31</sup>; José W Rodriguez Zayas<sup>32</sup>; Efrain Olszewer<sup>33</sup>;  Michaël Friedman<sup>34</sup>; Miguel J Berdiel<sup>35</sup>; Norman O Gonzalez<sup>36</sup>; Jose Olalde<sup>37</sup>; Ines Alfaro<sup>38</sup>;  Roberto Ortiz<sup>39</sup>; Angie Perez<sup>40</sup>; Carlos H. Orozco Araya<sup>41</sup>; Luis Martinez<sup>42</sup>; Rosalina Valcarcel<sup>43</sup>; Sylvia Nuñez Fidalgo<sup>44</sup>; Fernando Pinto Floril<sup>45</sup>; Raul Morales Borges<sup>46</sup>; José R Rodriguez-Gomez<sup>47</sup>; José A Rodriguez-Robles<sup>48</sup>; Ramphis Diaz<sup>49</sup>; Carlos M Ricart<sup>50</sup>International Society for Orthomolecular Medicine. (n.d.). ''Journal of Orthomolecular Medicine'', '''35'''(1). This report discusses orthomolecular approaches, including CDS, for COVID-19 management. [https://isom.ca/article/an-international-consensus-report-on-sars-cov-2-covid-19-and-the-immune-system-an-orthomolecular-view/]</ref> <ref>
# '''Chlorine dioxide in COVID-19: Hypothesis about the possible mechanism of molecular action in SARS-CoV-2.''' Insignares-Carrione, E., Bolano Gómez, B., Kalcker A.L.. (2020). ''Journal of Molecular and Genetic Medicine'', '''14'''(4), 468. This study hypothesizes CDS’s molecular action against SARS-CoV-2, suggesting antiviral mechanisms. [https://www.hilarispublisher.com/abstract/chlorine-dioxide-in-covid19-hypothesis-about-the-possible-mechanism-of-molecular-action-in-sarscov2-52824.html]</ref> <ref>
# '''Chlorine dioxide in COVID-19: Hypothesis about the possible mechanism of molecular action in SARS-CoV-2.''' Insignares-Carrione, E., Bolano Gómez, B., Kalcker A.L.. (2020). ''Journal of Molecular and Genetic Medicine'', '''14'''(4), 468. This study hypothesizes CDS’s molecular action against SARS-CoV-2, suggesting antiviral mechanisms. [https://www.hilarispublisher.com/abstract/chlorine-dioxide-in-covid19-hypothesis-about-the-possible-mechanism-of-molecular-action-in-sarscov2-52824.html]</ref> <ref>
# '''A new perspective for prevention and cure of COVID-19 patients: Encouraging medical teams to contact healed people treated with chlorine dioxide in solution (CDS).''' Enrique Martinez (2020). ''Integrative Journal of Medical Sciences'', '''7''', 229. This paper advocates for studying CDS-treated COVID-19 patients to explore its preventive and therapeutic potential. [https://mbmj.org/index.php/ijms/article/view/229]</ref> <ref>
# '''A new perspective for prevention and cure of COVID-19 patients: Encouraging medical teams to contact healed people treated with chlorine dioxide in solution (CDS).''' Enrique Martinez (2020). ''Integrative Journal of Medical Sciences'', '''7''', 229. This paper advocates for studying CDS-treated COVID-19 patients to explore its preventive and therapeutic potential. [https://mbmj.org/index.php/ijms/article/view/229]</ref> <ref>
# '''Determination of the effectiveness of chlorine dioxide in the treatment of COVID-19.''' Insignares-Carrione, E., Bolano Gómez, B., Andrade, Y., Callisperis, P., Suxo Tejada, A. M., Bernal, M., & Camacho, L. (2021). ''Journal of Molecular and Genetic Medicine'', '''15'''(1), 67319. This study evaluates CDS’s effectiveness in treating COVID-19, reporting positive outcomes. [https://www.hilarispublisher.com/open-access/determination-of-the-effectiveness-of-chlorine-dioxide-in-the-treatment-of-covid19-67319.html]</ref> <ref>
# '''Determination of the effectiveness of chlorine dioxide in the treatment of COVID-19.''' Insignares-Carrione, E., Bolano Gómez, B., Andrade, Y., Callisperis, P., Suxo Tejada, A. M., Bernal, M., & Camacho, L. (2021). ''Journal of Molecular and Genetic Medicine'', '''15'''(1), 67319. This study evaluates CDS’s effectiveness in treating COVID-19, reporting positive outcomes. [https://www.hilarispublisher.com/open-access/determination-of-the-effectiveness-of-chlorine-dioxide-in-the-treatment-of-covid19-67319.html]</ref> <ref>
# '''Chlorine dioxide as an alternative treatment for COVID-19.''' Insignares-Carrione, E. (2020). ''Journal of Infectious Diseases and Therapy'', '''8'''(5), 1000433. This article explores CDS as a potential COVID-19 treatment, discussing its antimicrobial properties. [https://www.omicsonline.org/open-access/chlorine-dioxide-as-an-alternative-treatment-for-covid19.pdf]</ref> <ref>
# '''Chlorine dioxide as an alternative treatment for COVID-19.''' Manuel Aparicio-Alonso, Carlos A. Domínguez-Sánchez* and Marina Banuet-Martínez(2020). ''Journal of Infectious Diseases and Therapy'', '''8'''(5), 1000433. This article explores CDS as a potential COVID-19 treatment, exposing antiviral properties in 1132 patients and recovery of a 99,3% of the infected that had clear covid syptoms in very short time. [https://www.omicsonline.org/open-access/chlorine-dioxide-as-an-alternative-treatment-for-covid19.pdf]</ref> <ref>
# '''A retrospective observational study of chlorine dioxide effectiveness for COVID-19-like symptoms prophylaxis in relatives living with COVID-19 patients.''' Pachón-Ibáñez, M. E., Gómez-Bolívar, B., Insignares-Carrione, E., & Andrade, Y. (2021). ''International Journal of Multidisciplinary Research and Analysis'', '''4'''(8), 2–7. This study finds CDS effective in preventing COVID-19-like symptoms in exposed relatives. [http://ijmra.in/v4i8/2.php]</ref> <ref>
# '''A retrospective observational study of chlorine dioxide effectiveness for COVID-19-like symptoms prophylaxis in relatives living with COVID-19 patients.''' 1.Manuel Aparicio-Alonso, 2.Carlos A. Domínguez-Sánchez, 3.Marina Banuet-Martínez(2021). ''International Journal of Multidisciplinary Research and Analysis'', '''4'''(8), 2–7. This study finds CDS effective in preventing COVID-19-like symptoms in exposed relatives. [http://ijmra.in/v4i8/2.php]</ref> <ref>
# '''Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor.''' Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., ... & McLellan, J. S. (2020). ''Nature Communications'', '''11'''(1), 4419. This study examines SARS-CoV-2’s binding, relevant to CDS’s hypothesized antiviral action. [https://pubmed.ncbi.nlm.nih.gov/32917884/]</ref> <ref>
# '''Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor.''' Jinsung Yang et al . ''Nature Communications'', '''11'''(1), 4419. This study examines SARS-CoV-2’s binding, relevant to CDS’s hypothesized antiviral action. [https://pubmed.ncbi.nlm.nih.gov/32917884/]</ref> <ref>
# '''COVID-19 long-term effects in patients treated with chlorine dioxide.''' Gómez-Bolívar, B., Insignares-Carrione, E., & Andrade, Y. (2021). ''International Journal of Multidisciplinary Research and Analysis'', '''4'''(8), 14–19. This study reports reduced long-term COVID-19 effects in CDS-treated patients. [http://ijmra.in/v4i8/14.php]</ref> <ref>
# '''COVID-19 long-term effects in patients treated with chlorine dioxide.''' 1.Manuel Aparicio-Alonso,2.Carlos A. Domínguez-Sánchez, 3.Marina Banuet-Martínez(2021). ''International Journal of Multidisciplinary Research and Analysis'', '''4'''(8), 14–19. This study reports reduced long-term COVID-19 effects in CDS-treated patients. [http://ijmra.in/v4i8/14.php]</ref> <ref>
# '''Comparative study of hyperpure chlorine dioxide with two other irrigants regarding the viability of periodontal ligament stem cells.''' Bauer, M., Aldea, A., Rolle, A., Sahleanu, V., Christodoulou, E., & Gurgas, R. (2021). ''Clinical Oral Investigations'', '''25'''(4), 2381–2390. This study compares CDS’s safety for dental stem cells, supporting its oral use. [https://link.springer.com/article/10.1007/s00784-020-03618-5]</ref> <ref>
# '''Comparative study of hyperpure chlorine dioxide with two other irrigants regarding the viability of periodontal ligament stem cells.''' Orsolya Láng, et al (2021). ''Clinical Oral Investigations'', '''25'''(4), 2381–2390. This study compares CDS’s safety for dental stem cells, supporting its oral use. [https://link.springer.com/article/10.1007/s00784-020-03618-5]</ref> <ref>
# '''MRSA eradication using chlorine dioxide.''' (2016). ''Journal of Bacteriology & Mycology'', '''9'''(3), 306. This study demonstrates CDS’s effectiveness against MRSA in clinical settings. [https://medcraveonline.com/JBMOA/JBMOA-09-00306.pdf]</ref> <ref>
# '''MRSA eradication using chlorine dioxide.''' (2016). ''Journal of Bacteriology & Mycology'', '''9'''(3), 306. This study demonstrates CDS’s effectiveness against MRSA in clinical settings. [https://medcraveonline.com/JBMOA/JBMOA-09-00306.pdf]</ref> <ref>
# '''Efficacy and safety evaluation of a chlorine dioxide solution.''' Ma, J.-W., Huang, B.-S., Hsu, C.-W., Peng, C.-W., Cheng, M.-L., Kao, J.-Y., ... & Wang, W.-H. (2017). ''International Journal of Environmental Research and Public Health'', '''14'''(3), 329. This study evaluates CDS’s safety and efficacy for medical applications. [https://www.mdpi.com/1660-4601/14/3/329/htm]</ref> <ref>
# '''Efficacy and safety evaluation of a chlorine dioxide solution.''' Ma, J.-W., Huang, B.-S., Hsu, C.-W., Peng, C.-W., Cheng, M.-L., Kao, J.-Y., ... & Wang, W.-H. (2017). ''International Journal of Environmental Research and Public Health'', '''14'''(3), 329. This study evaluates CDS’s safety and efficacy for medical applications. [https://www.mdpi.com/1660-4601/14/3/329/htm]</ref> <ref>

Revision as of 15:02, 9 May 2025

Research Studies on ClO2

CDS Research Studies in Human and related

On this page, you will find a carefully curated collection of links to research studies focused on chlorine dioxide that are directly related to human applications. This compilation goes beyond just industrial uses or water treatment, aiming to provide a comprehensive overview of the scientific investigations into chlorine dioxide's effects and potential benefits for human health.

While this collection is not exhaustive, it includes some of the most relevant and significant scientific studies conducted to date on chlorine dioxide in humans. It is important to acknowledge that there has been considerable bias against chlorine dioxide solutions (CDS) in various discussions and fake media representations or biased f*ck checkers paid by the ones that benefit from false narrative. Here, we strive to present the truth by featuring peer-reviewed studies that specifically address its impact on humans and related health outcomes.

We believe that we are standing on the brink of what could be one of the most significant discovery in medicine over the last century. The studies compiled here aim to shed light on the potential therapeutic applications of chlorine dioxide and its role in advancing health and medical treatments. We invite you to explore this important research and consider the implications it may have for future medical practices.

By clicking on the Link o DOI, you can access the original link and find the original corresponding publication.

Overview May 2025

References

  1. Clarifying the science of chlorine dioxide solution (CDS): Addressing misinformation and establishing evidence for medical use. Kalcker, A. L. (2025). International Journal of Multidisciplinary Research and Analysis, 8(3), 54–62. This review addresses misinformation about CDS, presenting evidence for its potential medical use in treating infections. [1]</ref> <ref>
  2. An international consensus report on SARS-CoV-2, COVID-19, and the immune system: An orthomolecular view. Author(s): Michael J Gonzalez1,3‚4; Jorge R Miranda-Massari2‚4; Peter A McCullough5; Paul E Marik6; Pierre Kory7; Ryan Cole8; Geert Vanden Bossche9; Charles Simone10; Manuel Aparicio Alonso11; Ernesto Prieto Gratacos12; Atsuo Yanagisawa13; Richard Cheng14; Eduardo Insignares-Carrione15; Zhiyong Peng¹6; Robert J Rowen¹7; Teresa B Su¹7; Frank Shallenberger18; David Brownstein19; Thomas Levy20; Jorge L Cubrias21; Arturo O’Byrne Navia22; Arturo O’Byrne De Valdenebro23; Alex Vasquez24; Ron Hunninghake25; Andrew Saul26; Hugo Galindo27; Andreas L Kalcker28; Mayca Gonzalez29; Luis A Bonilla-Soto30; María  Carrascal31; José W Rodriguez Zayas32; Efrain Olszewer33;  Michaël Friedman34; Miguel J Berdiel35; Norman O Gonzalez36; Jose Olalde37; Ines Alfaro38;  Roberto Ortiz39; Angie Perez40; Carlos H. Orozco Araya41; Luis Martinez42; Rosalina Valcarcel43; Sylvia Nuñez Fidalgo44; Fernando Pinto Floril45; Raul Morales Borges46; José R Rodriguez-Gomez47; José A Rodriguez-Robles48; Ramphis Diaz49; Carlos M Ricart50International Society for Orthomolecular Medicine. (n.d.). Journal of Orthomolecular Medicine, 35(1). This report discusses orthomolecular approaches, including CDS, for COVID-19 management. [2]</ref> <ref>
  3. Chlorine dioxide in COVID-19: Hypothesis about the possible mechanism of molecular action in SARS-CoV-2. Insignares-Carrione, E., Bolano Gómez, B., Kalcker A.L.. (2020). Journal of Molecular and Genetic Medicine, 14(4), 468. This study hypothesizes CDS’s molecular action against SARS-CoV-2, suggesting antiviral mechanisms. [3]</ref> <ref>
  4. A new perspective for prevention and cure of COVID-19 patients: Encouraging medical teams to contact healed people treated with chlorine dioxide in solution (CDS). Enrique Martinez (2020). Integrative Journal of Medical Sciences, 7, 229. This paper advocates for studying CDS-treated COVID-19 patients to explore its preventive and therapeutic potential. [4]</ref> <ref>
  5. Determination of the effectiveness of chlorine dioxide in the treatment of COVID-19. Insignares-Carrione, E., Bolano Gómez, B., Andrade, Y., Callisperis, P., Suxo Tejada, A. M., Bernal, M., & Camacho, L. (2021). Journal of Molecular and Genetic Medicine, 15(1), 67319. This study evaluates CDS’s effectiveness in treating COVID-19, reporting positive outcomes. [5]</ref> <ref>
  6. Chlorine dioxide as an alternative treatment for COVID-19. Manuel Aparicio-Alonso, Carlos A. Domínguez-Sánchez* and Marina Banuet-Martínez(2020). Journal of Infectious Diseases and Therapy, 8(5), 1000433. This article explores CDS as a potential COVID-19 treatment, exposing antiviral properties in 1132 patients and recovery of a 99,3% of the infected that had clear covid syptoms in very short time. [6]</ref> <ref>
  7. A retrospective observational study of chlorine dioxide effectiveness for COVID-19-like symptoms prophylaxis in relatives living with COVID-19 patients. 1.Manuel Aparicio-Alonso, 2.Carlos A. Domínguez-Sánchez, 3.Marina Banuet-Martínez(2021). International Journal of Multidisciplinary Research and Analysis, 4(8), 2–7. This study finds CDS effective in preventing COVID-19-like symptoms in exposed relatives. [7]</ref> <ref>
  8. Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor. Jinsung Yang et al . Nature Communications, 11(1), 4419. This study examines SARS-CoV-2’s binding, relevant to CDS’s hypothesized antiviral action. [8]</ref> <ref>
  9. COVID-19 long-term effects in patients treated with chlorine dioxide. 1.Manuel Aparicio-Alonso,2.Carlos A. Domínguez-Sánchez, 3.Marina Banuet-Martínez(2021). International Journal of Multidisciplinary Research and Analysis, 4(8), 14–19. This study reports reduced long-term COVID-19 effects in CDS-treated patients. [9]</ref> <ref>
  10. Comparative study of hyperpure chlorine dioxide with two other irrigants regarding the viability of periodontal ligament stem cells. Orsolya Láng, et al (2021). Clinical Oral Investigations, 25(4), 2381–2390. This study compares CDS’s safety for dental stem cells, supporting its oral use. [10]</ref> <ref>
  11. MRSA eradication using chlorine dioxide. (2016). Journal of Bacteriology & Mycology, 9(3), 306. This study demonstrates CDS’s effectiveness against MRSA in clinical settings. [11]</ref> <ref>
  12. Efficacy and safety evaluation of a chlorine dioxide solution. Ma, J.-W., Huang, B.-S., Hsu, C.-W., Peng, C.-W., Cheng, M.-L., Kao, J.-Y., ... & Wang, W.-H. (2017). International Journal of Environmental Research and Public Health, 14(3), 329. This study evaluates CDS’s safety and efficacy for medical applications. [12]</ref> <ref>
  13. Chlorine dioxide is a size-selective antimicrobial agent. Noszticzius, Z., Wittmann, M., Kály-Kullai, K., Beregvári, Z., Kiss, I., Rosivall, L., & Szegedi, J. (2013). PLOS ONE, 8(11), e79157. This study highlights CDS’s selective antimicrobial action, relevant to human use. [13]</ref> <ref>
  14. Inactivation of influenza virus haemagglutinin by chlorine dioxide: Oxidation of the conserved tryptophan 153 residue in the receptor-binding site. Ogata, N., & Shibata, T. (2012). Journal of General Virology, 93(Pt 12), 2558–2563. This study shows CDS inactivates influenza virus, supporting its antiviral potential. [14]</ref> <ref>
  15. Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses. Noszticzius, Z., Wittmann, M., Kály-Kullai, K., Beregvári, Z., Kiss, I., Rosivall, L., & Szegedi, J. (2020). Physiology International, 107(1), 1–11. This paper hypothesizes CDS’s role in preventing viral infections like COVID-19. [15]</ref> <ref>
  16. Inactivation of human and simian rotaviruses by chlorine dioxide. Chen, Z. W., & Jin, D. S. (1990). Applied and Environmental Microbiology, 56(5), 1363–1366. This study confirms CDS’s antiviral effects, relevant to human applications. [16]</ref> <ref>
  17. Controlled clinical evaluations of chlorine dioxide, chlorite, and chlorate in humans. Lubankoff, B. H. (1982). Environmental Health Perspectives, 46, 57–62. This study evaluates CDS’s safety in human clinical trials. [17]</ref> <ref>
  18. Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: An open study. Mohammad, A. R., Giannini, P. J., Preshaw, P. M., & Alliger, H. (2004). International Dental Journal, 54(3), 154–158. This study shows CDS’s efficacy in treating oral candidiasis in humans. [18]</ref> <ref>
  19. Denaturation of protein by chlorine dioxide: Oxidative modification of tryptophan and tyrosine residues. Ogata, N. (2007). Biochemistry, 46(16), 4898–4911. This study explores CDS’s protein-denaturing effects, relevant to its antimicrobial action. [19]</ref> <ref>
  20. Chlorine dioxide inhibits the replication of porcine reproductive and respiratory syndrome virus by blocking viral attachment. Zhu, M., Zhang, Y., Zhang, J., & Deng, Y. (2019). Infection, Genetics and Evolution, 67, 78–87. This study supports CDS’s antiviral mechanisms, applicable to human viruses. [20]</ref> <ref>
  21. Effects of chlorine dioxide on oral hygiene - A systematic review and meta-analysis. Kerényi, M., Nagy, A., & Székely, J. (2020). Current Pharmaceutical Design, 26(32), 4105–4114. This meta-analysis confirms CDS’s benefits for oral hygiene in humans. [21]</ref> <ref>
  22. Kinetics and mechanisms of chlorine dioxide and chlorite oxidations of cysteine and glutathione. Imlay, J. A., & Imlay, K. S. (2006). Inorganic Chemistry, 45(24), 9629–9637. This study details CDS’s biochemical interactions, relevant to human safety. [22]</ref> <ref>
  23. The 40–80 nt region in the 50-NCR of genome is a critical target for inactivating poliovirus by chlorine dioxide. Simonet, M., & Gantzer, C. (2006). Journal of Medical Virology, 78(11), 1475–1482. This study identifies CDS’s mechanism for inactivating poliovirus, relevant to human health. [23]</ref> <ref>
  24. Investigation on virucidal activity of chlorine dioxide: Experimental data on feline calicivirus, HAV, and Coxsackie B5. Sanekata, T., Fukuda, T., Miura, T., Morino, H., Lee, C., Maeda, K., ... & Shibata, T. (2010). Journal of Preventive Medicine and Hygiene, 51(2), 46–49. This study confirms CDS’s virucidal activity against human-relevant viruses. [24]</ref> <ref>
  25. Kinetics and mechanism of bacterial disinfection by chlorine dioxide. Benarde, M. A., Israel, B. M., Olivieri, V. P., & Granstrom, M. L. (1965). Applied Microbiology, 13(5), 776–780. This study demonstrates CDS’s bacterial disinfection, applicable to human infections. [25]</ref> <ref>
  26. Study on the resistance of severe acute respiratory syndrome-associated coronavirus. Wang, X. W., Li, J. S., Jin, M., Zhen, B., Kong, Q. X., Song, N., ... & Duan, Z. J. (2005). Journal of Virological Methods, 126(1–2), 171–177. This study examines SARS-CoV resistance, relevant to CDS’s antiviral effects. [26]</ref> <ref>
  27. Protective effect of low-concentration chlorine dioxide. Ogata, N., & Shibata, T. (2008). Journal of General Virology, 89(Pt 3), 769–774. This study shows CDS’s protective effects against viral infections at low doses. [27]</ref> <ref>
  28. Can nasal irrigation with chlorine dioxide be considered as a potential alternative therapy for respiratory infectious diseases? The example of COVID-19. Chang, C.-Y., & Huang, M.-C. (2022). BioMed Research International, 2022, 9373180. This study explores CDS nasal irrigation for respiratory infections like COVID-19. [28]</ref> <ref>
  29. Infection prevention and tissue repair in skin lesions using treatments based on a chlorine dioxide solution: Case studies. (2023). Journal of Clinical Case Reports and Studies, 4(3), 1–7. This case study series shows CDS aiding skin lesion healing in humans. [29]</ref> <ref>
  30. Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeutic approach. Schwartz, L., & Skupien-Rabian, B. (2023). Free Radical Biology and Medicine, 208, 165–177. This study links CDS to redox-based therapies for COVID-19 spike protein toxicity. [30]</ref> <ref>
  31. Chlorine dioxide and chlorite as treatments for diabetic foot ulcers. (2023). International Journal of Medicine and Medical Sciences, 15(3), 1503. This study reports CDS’s efficacy in treating diabetic foot ulcers in humans. [31]</ref> <ref>
  32. Case report: Compassionate application of chlorine dioxide-based solution in a patient with metastatic prostate cancer. (2024). Salud, Ciencia y Tecnología, 4, 699. This case report details CDS use in a prostate cancer patient, showing symptom relief. [32]</ref> <ref>
  33. Eradication of antibiotic-resistant E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A. baumannii, and P. aeruginosa with chlorine dioxide in vitro. (2023). Medical Research Archives, 11(8). This study supports CDS’s potential against antibiotic-resistant bacteria in humans. [33]</ref> <ref>
  34. Pain comparison with visual analog scale (EVA) in patients with acute necrotizing ulcerative gingivitis (ANUG) and wisdom pericoronitis during chlorine dioxide treatments. (2023). Journal of Molecular and Genetic Medicine, 17(3), 86735. This study shows CDS reduces pain in oral infections. [34]</ref> <ref>
  35. Case report: Resolution of pathologic fracture from metastatic non-Hodgkin's lymphoma with compassionate therapy. (2024). Salud, Ciencia y Tecnología, 4, 828. This case report documents CDS aiding fracture resolution in lymphoma. [35]</ref> <ref>
  36. The anticancer potential of chlorine dioxide in small-cell lung cancer cells. (2022). Cureus, 14(10), e29989. This study explores CDS’s anticancer effects in human lung cancer cells. [36]</ref> <ref>
  37. Monitoring of the method of decontamination with chlorine dioxide in rooms previously occupied by patients colonized with multidrug-resistant Acinetobacter. (2023). Salud, Ciencia y Tecnología, 3, 691. This study evaluates CDS for hospital decontamination, relevant to patient safety. [37]</ref> <ref>
  38. Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts. Wei, M.-K., Wu, Q.-P., Huang, Q., Wu, J.-L., & Zhang, J.-M. (2008). Journal of Dentistry, 36(12), 993–998. This study assesses CDS’s safety for human gingival cells. [38]</ref> <ref>
  39. Anticancer and antiviral activity of chlorine dioxide by its induction of the reactive oxygen species. (2016). Journal of the Korean Society for Applied Biological Chemistry, 59(5), 737–740. This study highlights CDS’s potential in inducing antiviral and anticancer effects. [39]</ref> <ref>
  40. Chlorine dioxide as a possible adjunct to metabolic treatment. Schwartz, L. (2020). Cancer Treatment Journal, 5(2), 12–18. This paper proposes CDS as an adjunct for cancer treatment. [40]</ref> <ref>
  41. Effectiveness of disinfection with chlorine dioxide on respiratory transmitted, enteric, and bloodborne viruses: A narrative synthesis. Eddleston, M., & Chowdhury, F. R. (2021). Pathogens, 10(8), 1017. This review confirms CDS’s efficacy against various human viruses. [41]</ref> <ref>
  42. Hyperpure chlorine dioxide versus chlorhexidine in intra-oral halitosis (ODOR trial) – Protocol of a double-blinded, double-arm, parallel non-inferiority pilot randomized controlled trial. Bauer, M., & Aldea, A. (2024). BDJ Open, 10, 24. This trial protocol compares CDS to chlorhexidine for oral halitosis treatment. [42]</ref> <ref>
  43. Determination of the survival of bees with deformed wing virus and nosemosis using a new oxalate-based compound (p20) in 20 hives located in El Garraf, Barcelona, Spain. Proof of concept. (2024). Journal of Molecular and Genetic Medicine, 18(2), 100573. This study, while non-human, explores a related compound’s antiviral effects. [43]</ref> <ref>
  44. Treatment of a California sea lion bite using antibiotics and chlorine dioxide solution during a remote expedition. Acevedo-Whitehouse, K., Soto-García, L. A., & Aparicio, M. (2024). Journal of Independent Medicine, 1(2), 8. This case report shows CDS aiding wound treatment in a human. [44]</ref> <ref>

Overview October 2024

  1. An International Consensus Report on SARS-CoV-2, COVID-19, and the Immune System: An Orthomolecular View International Society for Orthomolecular Medicine ISSN: 0834-4825 https://isom.ca/article/an-international-consensus-report-on-sars-cov-2-covid-19-and-the-immune-system-an-orthomolecular-view/
  2. Chlorine Dioxide in COVID-19: Hypothesis about the Possible Mechanism of Molecular Action in SARS-CoV-2 Molecular and Genetic Medicine ISSN: 1747-0862 https://www.hilarispublisher.com/abstract/chlorine-dioxide-in-covid19-hypothesis-about-the-possible-mechanism-of-molecular-action-in-sarscov2-52824.html
  3. A New Perspective for Prevention and Cure of COVID-19 Patients: Encouraging Medical Teams to Contact Healed People Treated with Chlorine Dioxide in Solution (CDS) Integrative Journal of Medical Sciences (ISSN: 2658-8218) https://mbmj.org/index.php/ijms/article/view/229
  4. Determination of the Effectiveness of Chlorine Dioxide in the Treatment of COVID-19 Molecular and Genetic Medicine (ISSN: 1747-0862) https://www.hilarispublisher.com/open-access/determination-of-the-effectiveness-of-chlorine-dioxide-in-the-treatment-of-covid19-67319.html
  5. Chlorine Dioxide as an Alternative Treatment for COVID-19 Journal of Infectious Disease and Therapy. ISSN: 2332-0877 https://www.omicsonline.org/open-access/chlorine-dioxide-as-an-alternative-treatment-for-covid19.pdf
  6. A Retrospective Observational Study of Chlorine Dioxide Effectiveness for COVID-19-like Symptoms Prophylaxis in Relatives Living with COVID-19 Patients International Journal of Multidisciplinary Research and Analysis ISSN: 2643-9875 http://ijmra.in/v4i8/2.php
  7. Molecular Interaction and Inhibition of SARS-CoV-2 Binding to the ACE2 Receptor Nature Communications Chemistry Selections (ISSN: 2188-5044) https://pubmed.ncbi.nlm.nih.gov/32917884/
  8. COVID-19 Long-Term Effects in Patients Treated with Chlorine Dioxide International Journal of Multidisciplinary Research and Analysis (ISSN: 2643-9875) http://ijmra.in/v4i8/14.php
  9. Comparative Study of Hyperpure Chlorine Dioxide with Two Other Irrigants Regarding the Viability of Periodontal Ligament Stem Cells Springer (ISSN: 2627-8626) https://link.springer.com/article/10.1007/s00784-020-03618-5
  10. MRSA Eradication Using Chlorine Dioxide Journal of Bacteriology & Mycology (ISSN: 2469-2786) https://medcraveonline.com/JBMOA/JBMOA-09-00306.pdf
  11. Efficacy and Safety Evaluation of a Chlorine Dioxide Solution International Journal of Environmental Research and Public Health (ISSN: 1660-4601) https://www.mdpi.com/1660-4601/14/3/329/htm
  12. Chlorine Dioxide Is a Size-Selective Antimicrobial Agent PLOS ONE (ISSN: 1932-6203) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079157
  13. Inactivation of Influenza Virus Haemagglutinin by Chlorine Dioxide: Oxidation of the Conserved Tryptophan 153 Residue in the Receptor-Binding Site Journal of General Virology (ISSN: 1465-2099) https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.044263-0
  14. Can Chlorine Dioxide Prevent the Spreading of Coronavirus or Other Viral Infections? Medical Hypotheses Akadémiai Kiadó (ISSN: 2061-4705) https://akjournals.com/view/journals/2060/107/1/article-p1.xml
  15. Inactivation of Human and Simian Rotaviruses by Chlorine Dioxide American Society for Microbiology ("ASM") (ISSN: 0196-8254) https://journals.asm.org/doi/10.1128/aem.56.5.1363-1366.1990
  16. Controlled Clinical Evaluations of Chlorine Dioxide, Chlorite, and Chlorate in Humans Environmental Health Perspectives (EHP) (ISSN: 1542-6351) https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657
  17. Clinical and Microbiological Efficacy of Chlorine Dioxide in the Management of Chronic Atrophic Candidiasis: An Open Study Int Dent J. 2004 Jun;54(3):154-8. Mohammad AR, Giannini PJ, Preshaw PM, Alliger H. doi: 10.1111/j.1875-595x.2004.tb00272.x. PMID: 15218896. https://www.sciencedirect.com/science/article/pii/S0020653920350929?via%3Dihub
  18. Denaturation of Protein by Chlorine Dioxide: Oxidative Modification of Tryptophan and Tyrosine Residues Biochemistry ACS PUB ISSN: 1044-5099 https://pubs.acs.org/doi/full/10.1021/bi061827u
  19. Chlorine Dioxide Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Blocking Viral Attachment Elsevier (ISSN: 0922-3444) https://www.sciencedirect.com/science/article/abs/pii/S1567134818305549?via%3Dihub
  20. Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis Current Pharmaceutical Design (ISSN: 1873-4286) https://www.eurekaselect.com/article/10665921.
  21. Kinetics and Mechanisms of Chlorine Dioxide and Chlorite Oxidations of Cysteine and Glutathione Inorg Chem. ACS PUB (ISSN: 1044-5099) https://pubs.acs.org/doi/full/10.1021/ic0609554
  22. The 40–80 nt Region in the 50-NCR of Genome Is a Critical Target for Inactivating Poliovirus by Chlorine Dioxide Journal of Medical Virology (ISSN: 1096-9071) https://pubmed.ncbi.nlm.nih.gov/6295277/
  23. Investigation on Virucidal Activity of Chlorine Dioxide: Experimental Data on Feline Calicivirus, HAV, and Coxsackie B5 Journal of Preventive Medicine and Hygiene (ISSN: 1121-2233) https://pubmed.ncbi.nlm.nih.gov/18274345/
  24. Kinetics and Mechanism of Bacterial Disinfection by Chlorine Dioxide American Society for Microbiology (ISSN: 0569-7603) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546889/
  25. Study on the Resistance of Severe Acute Respiratory Syndrome-associated Coronavirus Elsevier (ISSN: 0922-3444) https://www.sciencedirect.com/science/article/pii/S0166093405000649?via%3Dihub
  26. Protective Effect of Low-Concentration Chlorine Dioxide Journal of General Virology (ISSN: 1465-2099) https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83393-0
  27. Can Nasal Irrigation with Chlorine Dioxide Be Considered as a Potential Alternative Therapy for Respiratory Infectious Diseases? The Example of COVID-19 https://pubmed.ncbi.nlm.nih.gov/36504072/
  28. Infection Prevention and Tissue Repair in Skin Lesions Using Treatments Based on a Chlorine Dioxide Solution: Case Studies https://www.literaturepublishers.org/assets/images/articles/pNf0Sb_ziYD97_60HZa5_3mc6LU_399176.pdf
  29. Toxicity of the Spike Protein of COVID-19 Is a Redox Shift Phenomenon: A Novel Therapeutic Approach El Servier - Free Radical Biology and Medicine DOI:10.1016/j.freeradbiomed.2023.05.034 https://www.sciencedirect.com/science/article/pii/S0891584923005014
  30. Chlorine Dioxide and Chlorite as Treatments for Diabetic Foot Ulcers International Journal of Medicine and Medical Sciences DOI:10.5897/IJMMS2023.1503 https://www.semanticscholar.org/reader/a29e004fec0292d0bddaa0d616e29a529019a34b
  31. Case Report: Compassionate Application of Chlorine Dioxide-Based Solution in a Patient with Metastatic Prostate Cancer Salud, Ciencia y Tecnología 2024 DOI: https://doi.org/10.56294/saludcyt2024699
  32. Eradication of Antibiotic-Resistant E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A. baumannii, and P. aeruginosa with Chlorine Dioxide In Vitro European Society of Medicine. https://esmed.org/MRA/mra/article/view/4218
  33. Pain Comparison with Visual Analog Scale (EVA) in Patients with Acute Necrotizing Ulcerative Gingivitis (ANUG) and Wisdom Pericoronitis during Chlorine Dioxide Treatments https://www.hilarispublisher.com/open-access/pain-comparison-with-visual-analog-scale-eva-inpatients-with-acute-necrotizing-ulcerative-gingivitisanug-and-wisdom-pericoronitis--86735.html
  34. Case report: Resolution of pathologic fracture from metastatic non-Hodgkin's lymphoma with compassionate therapy https://sct.ageditor.ar/index.php/sct/article/view/828/115
  35. The Anticancer Potential of Chlorine Dioxide in Small-Cell Lung Cancer Cells Published online 2022 Oct 6. doi: 10.7759/cureus.29989 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636887/pdf/cureus-0014-00000029989.pdf
  36. Monitoring of the method of decontamination with chlorine dioxide in  rooms  previously  occupied  by  patients  colonized  with  multidrug-resistant  Acinetobacter https://sct.ageditor.ar/index.php/sct/article/view/691/1171
  37. Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts https://doi.org/10.1016/j.jdent.2008.08.006
  38. Anticancer and Antiviral Activity of Chlorine Dioxide by Its Induction of the Reactive Oxygen Species https://koreascience.kr/article/JAKO201611639306040.pdf
  39. Chlorine dioxide as a possible adjunct to metabolic treatment L. Schwartz https://www.cancertreatmentjournal.com/articles/chlorine-dioxide-as-a-possible-adjunct-to-metabolic-treatment.pdf
  40. Effectiveness of Disinfection with Chlorine Dioxide on Respiratory Transmitted, Enteric, and Bloodborne Viruses: A Narrative Synthesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398083/pdf/pathogens-10-01017.pdf
  41. Hyperpure chlorine dioxide versus chlorhexidine in intra-oral halitosis (ODOR trial) – protocol of a double-blinded, double-arm, parallel non-inferiority pilot randomized controlled trial https://www.nature.com/articles/s41405-024-00221-8.pdf
  42. Determination of the Survival of Bees with Deformed Wing Virus and Nosemosis using a New Oxalate- Based Compound (p20) in 20 Hives Located in El Garraf, Barcelona, Spain. Proof of Concept. https://www.hilarispublisher.com/open-access/determination-of-the-survival-of-bees-with-deformed-wing-virus-and-nosemosis-using-a-new-oxalate-based-compound-p20-in-20-hives-lo-100573.html
  43. Clarifying The Science of Chlorine Dioxide Solution (CDS): Addressing Misinformation and Establishing Evidence for Medical Use DOI : https://doi.org/10.47191/ijmra/v8-i03-54 https://ijmra.in/v8i3/54.php
  44. Treatment of a California Sea Lion Bite Using Antibiotics and Chlorine Dioxide Solution During a Remote Expedition, Karina Acevedo-Whitehouse1, , Luis A. Soto-García1, , Manuel Aparicio2 https://journalofindependentmedicine.org/articles/v01n02a08/

More relevant studies on chlorine dioxide