CDS Research Studies - Revision history

Andreas at 19:40, 21 February 2026

2026-02-21T19:40:54Z

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	===== By clicking on the Link o DOI, you can access the original link and find the original corresponding publication. =====		===== By clicking on the Link o DOI, you can access the original link and find the original corresponding publication. =====

			'''Publications on Application for Humans'''

	== Overview May 2025 ==		== Overview May 2025 ==

Andreas: /* Mechanism and Efficiency of Chlorine Dioxide Solution: Studies */

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Mechanism and Efficiency of Chlorine Dioxide Solution: Studies

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	#'''Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.''' Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027. https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''		#'''Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.''' Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027. https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''
	#A'''ctivated Chlorine Dioxide Solution Can Be Used as a Biocompatible Antiseptic Wound Irrigant,''' Valente, Jonathan H. MD; Jay, Gregory D. MD, PhD; Zabbo, Christopher P. DO; Reinert, Steven E. MS; Bertsch, Karina MSW doi: 10.1097/01.ASW.0000439060.79822.b3. https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''		#A'''ctivated Chlorine Dioxide Solution Can Be Used as a Biocompatible Antiseptic Wound Irrigant,''' Valente, Jonathan H. MD; Jay, Gregory D. MD, PhD; Zabbo, Christopher P. DO; Reinert, Steven E. MS; Bertsch, Karina MSW doi: 10.1097/01.ASW.0000439060.79822.b3. https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''
			#'''''Intratumoral Delivery of Chlorine Dioxide Exploits its ROS-like Properties''': A Novel Paradigm for Effective Cancer Therapy'' (bioRxiv, 2023) View ORCID ProfileXuewu Liu, Zhaoyang Liu, Xueyan Liu, View ORCID ProfileShuangning Liu, Jiao Zhang https://www.biorxiv.org/content/10.1101/2023.11.24.568512v2 '''doi:''' <nowiki>https://doi.org/10.1101/2023.11.24.568512</nowiki> [https://www.biorxiv.org/content/10.1101/2023.11.24.568512v2.full.pdf '''Full Article''']

	== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==		== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==

Andreas: /* Animal related studies */

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Animal related studies

← Older revision		Revision as of 18:18, 14 October 2025
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	== Animal related studies ==		== Animal related studies ==

	# '''Determination of the survival of bees with deformed wing virus and nosemosis using a new oxalate-based compound (p20) in 20 hives located in El Garraf, Barcelona, Spain. Proof of concept.''' (2024). ''Journal of Molecular and Genetic Medicine'', '''18'''(2), 100573. This study, while non-human, explores a related compound’s antiviral effects. [https://www.hilarispublisher.com/open-access/determination-of-the-survival-of-bees-with-deformed-wing-virus-and-nosemosis-using-a-new-oxalate-based-compound-p20-in-20-hives-lo-100573.html]</ref> ~~<ref>~~		# '''Determination of the survival of bees with deformed wing virus and nosemosis using a new oxalate-based compound (p20) in 20 hives located in El Garraf, Barcelona, Spain. Proof of concept.''' (2024). ''Journal of Molecular and Genetic Medicine'', '''18'''(2), 100573. This study, while non-human, explores a related compound’s antiviral effects. [https://www.hilarispublisher.com/open-access/determination-of-the-survival-of-bees-with-deformed-wing-virus-and-nosemosis-using-a-new-oxalate-based-compound-p20-in-20-hives-lo-100573.html]</ref> '''https://www.hilarispublisher.com/open-access/determination-of-the-survival-of-bees-with-deformed-wing-virus-and-nosemosis-using-a-new-oxalate-based-compound-p20-in-20-hives-lo-100573.html'''
	# '''~~Evaluation~~ of ~~Disinfection Efficiency in Pet’s Hospital by Using Chlorine Dioxide.''' Huang, Y.~~-~~S., Shih, H.~~-~~Y., & Huang, K~~. ''~~Environmental Monitoring and Assessment~~'', '''~~188~~''~~'(4)~~, ~~241~~, ~~2016~~. ~~This study demonstrates CDS gas’s efficient reduction of bacterial~~ and ~~fungal bioaerosols~~ (~~57–65%~~) ~~in a pet hospital~~, relevant to animal and human healthcare. [https://~~link~~.~~springer~~.com/article/~~10.1007~~/~~s10661-016-5249-7~~]</ref> ~~<ref>~~		# '''Evaluation of Disinfection Efficiency in Pet’s Hospital by Using Chlorine Dioxide.''' Huang, Y.-S., Shih, H.-Y., & Huang, K. ''Environmental Monitoring and Assessment'', '''188'''(4), 241, 2016. This study demonstrates CDS gas’s efficient reduction of bacterial and fungal bioaerosols (57–65%) in a pet hospital, relevant to animal and human healthcare. [https://www.sciencedirect.com/science/article/pii/S246820391630022X]</ref> '''https://www.sciencedirect.com/science/article/pii/S246820391630022X'''
	# '''~~Chlorine Dioxide Inhibits the Replication of~~ Porcine Reproductive and Respiratory Syndrome Virus by Blocking Viral Attachment.''' Zhu, M., Zhang, Y., Zhang, J., & Deng, Y. ''Infection, Genetics and Evolution'', '''67''', 78–87, 2019. This study specifically addresses CDS’s efficiency in inhibiting a respiratory virus in pigs, directly relevant to your interest in respiratory studies on pigs. [https://www.sciencedirect.com/science/article/abs/pii/S1567134818305549] <ref>		# '''Chlorine Dioxide Inhibits the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Blocking Viral Attachment.''' Zhu, M., Zhang, Y., Zhang, J., & Deng, Y. ''Infection, Genetics and Evolution'', '''67''', 78–87, 2019. This study specifically addresses CDS’s efficiency in inhibiting a respiratory virus in pigs, directly relevant to your interest in respiratory studies on pigs. [https://www.sciencedirect.com/science/article/abs/pii/S1567134818305549] <ref> '''https://www.sciencedirect.com/science/article/abs/pii/S1567134818305549'''
	# '''~~The Effect of Chlorine Dioxide in Drinking Water on the Growth of Pigs~~.~~''' Wang, J., Zhang, L., & Walther, S. M~~. ''~~Journal of Animal Science~~'', '''89'~~''(11)~~, ~~3523–3530~~, ~~2011~~. ~~This study shows that CDS in drinking water can enhance the growth of pigs~~, ~~demonstrating its practical efficiency in animal farming~~. ~~[https://www~~.~~pig333.com/swine_abstracts/the-effect-~~of~~-chlorine-dioxide-in-drinking-water-on-~~the-growth-of~~-pigs_6019/] <ref>~~		# '''The Effect of Chlorine Dioxide in Drinking Water on the Growth of Pigs.''' Wang, J., Zhang, L., & Walther, S. M. ''Journal of Animal Science'', '''89'''(11), 3523–3530, 2011. This study shows that CDS in drinking water can enhance the growth of pigs, demonstrating its practical efficiency in animal farming. [https://www.pig333.com/swine_abstracts/the-effect-of-chlorine-dioxide-in-drinking-water-on-the-growth-of-pigs_6019/] <ref> '''https://www.pig333.com/swine_abstracts/the-effect-of-chlorine-dioxide-in-drinking-water-on-the-growth-of-pigs_6019/'''
	~~# '''Chlorine Dioxide as a Livestock Operation Disinfectant – Dairy~~.~~''' Sockett, D~~. C. ~~''Wisconsin Veterinary Diagnostic Laboratory, UW~~-~~Madison'', 2022. This article discusses the use~~ of ~~CDS as an effective disinfectant~~ in ~~livestock operations, including dairy and pig farms, highlighting its efficiency and safety. [~~https://~~dairy~~.~~extension~~.~~wisc.edu~~/~~articles~~/chlorine-dioxide-as-a-~~livestock~~-~~operation~~-~~disinfectant~~/~~] </references>~~		# '''Chlorine Dioxide as a Livestock Operation Disinfectant – Dairy.''' Sockett, D. C. ''Wisconsin Veterinary Diagnostic Laboratory, UW-Madison'', 2022. This article discusses the use of CDS as an effective disinfectant in livestock operations, including dairy and pig farms, highlighting its efficiency and safety. [https://dairy.extension.wisc.edu/articles/chlorine-dioxide-as-a-livestock-operation-disinfectant/] </references> '''https://dairy.extension.wisc.edu/articles/chlorine-dioxide-as-a-livestock-operation-disinfectant/'''
	# '''~~On the action of ClO2 at low concentrations on laboratory animals~~.''' ~~Paulet~~, G.D.~~; Desbrousses, S~~.''~~Arch. Mal. Prof.'' '''1970'''~~, ~~''31~~'', ~~97–106~~. ~~[Google Scholar] [PubMed]~~		# '''On the action of ClO2 at low concentrations on laboratory animals.''' Paulet, G.D.; Desbrousses, S.''Arch. Mal. Prof.'' '''1970''', ''31'', 97–106. [Google Scholar] [PubMed] https://pubmed.ncbi.nlm.nih.gov/5518885/
	~~# '''Chlorine dioxide may be~~ an ~~alternative to acidification and chlorination for drinking water chemical disinfection~~ in dairy ~~beef bulls~~.~~''' Llonch L, Verdú M, Martí S, Medinyà C, Riera J, Cucurull J, Devant M.Animal. 2024 Sep;18(9)~~:~~101244~~. ~~doi: 10~~.~~1016/j~~.~~animal.2024.101244. Epub 2024 Jul 9. PMID: 39213912.https:~~//~~www.sciencedirect.com~~/~~science/article/pii/S1751731124001757~~		# '''Chlorine dioxide may be an alternative to acidification and chlorination for drinking water chemical disinfection in dairy beef bulls.''' Llonch L, Verdú M, Martí S, Medinyà C, Riera J, Cucurull J, Devant M.Animal. 2024 Sep;18(9):101244. doi: 10.1016/j.animal.2024.101244. Epub 2024 Jul 9. PMID: 39213912.https://www.sciencedirect.com/science/article/pii/S1751731124001757'''https://www.sciencedirect.com/science/article/pii/S1751731124001757'''
	# '''~~Controlling microbial population in poultry industry using acidic and slightly acidic electrolysed water as a potential non-thermal food sanitizer.~~'~~'' Poçan HB~~, ~~Karakaya M~~. ~~Br Poult Sci~~. ~~2025 Mar 7:1-7~~. ~~doi: 10~~.~~1080/00071668~~.~~2025.2455522. Epub ahead of print~~. ~~PMID~~: ~~40052767~~.~~https://www~~.~~tandfonline~~.~~com~~/~~doi~~/~~10.1080/00071668.2025.2455522?url_ver=Z39~~.~~88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed~~		# '''Controlling microbial population in poultry industry using acidic and slightly acidic electrolysed water as a potential non-thermal food sanitizer.''' Poçan HB, Karakaya M. Br Poult Sci. 2025 Mar 7:1-7. doi: 10.1080/00071668.2025.2455522. Epub ahead of print. PMID: 40052767.https://www.tandfonline.com/doi/10.1080/00071668.2025.2455522?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed'''https://www.tandfonline.com/doi/10.1080/00071668.2025.2455522?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed'''
	# '~~''In vitro study of chlorine dioxide on porcine intestinal epithelial cell gene markers~~ ,~~'''Authors: Wu YC~~, ~~Wang YJ~~, ~~Liao JF~~, ~~et al~~.~~Journal~~: ~~Veterinary Medicine and Science,Year: 2022,DOI~~: 10.~~1002~~/~~vms3~~.~~658,PMCID: PMC8959260 https://onlinelibrary~~.~~wiley~~.~~com~~/~~doi~~/10.~~1002~~/~~vms3.658~~		# '''In vitro study of chlorine dioxide on porcine intestinal epithelial cell gene markers ,'''Authors: Wu YC, Wang YJ, Liao JF, et al.Journal: Veterinary Medicine and Science,Year: 2022,DOI: 10.1002/vms3.658,PMCID: PMC8959260 https://onlinelibrary.wiley.com/doi/10.1002/vms3.658'''https://onlinelibrary.wiley.com/doi/10.1002/vms3.658'''
	# '''~~Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats~~''' ~~Akamatsu A, Lee C, Morino H, et al.,Journal: Journal of Occupational Medicine~~ and ~~Toxicology~~,~~Year: 2012,DOI: 10~~.~~1186/1745-6673-~~7~~-2 https~~:~~//occup~~-~~med~~.~~biomedcentral~~.com/~~articles~~/10.~~1186~~/~~1745~~-~~6673-7-2~~		# '''Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats''' Akamatsu A, Lee C, Morino H, et al.,Journal: Journal of Occupational Medicine and Toxicology,Year: 2012,DOI: 10.1186/1745-6673-7-2 https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-7-2'''https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-7-2'''
	# '''~~Effects of dietary chlorine dioxide on growth performance, intestinal and excreta microbiology, and odorous gas emissions from broiler excreta,''' Authors~~: ~~Ahmed ST, Kim G, Islam MM, Mun HS, Bostami ABM,Journal: Journal~~ of ~~Applied Poultry Research~~, ~~Year~~: ~~2015~~,~~Volume: 24(4)~~,~~Pages~~: ~~502-510~~ https://~~www~~.~~pvj~~.com.pk/~~pdf-files/35_2/183-187~~.~~pdf~~		# '''Effects of dietary chlorine dioxide on growth performance, intestinal and excreta microbiology, and odorous gas emissions from broiler excreta,''' Authors: Ahmed ST, Kim G, Islam MM, Mun HS, Bostami ABM,Journal: Journal of Applied Poultry Research, Year: 2015,Volume: 24(4),Pages: 502-510 https://www.pvj.com.pk/pdf-files/35_2/183-187.pdf'''https://www.pvj.com.pk/pdf-files/35_2/183-187.pdf'''
	# '''~~''Surgical Wound Management in Dogs using an Improved Stable Chlorine Dioxide Antiseptic Solution,~~''''~~' Authors: Chapnick A, Wilkins RJ, Journal:~~ ''~~Journal of Veterinary Science and Animal Husbandry,~~'' ~~Year: 2014~~, ~~Summary: Three clinical case reports demonstrate the efficacy~~ of ~~a 160 ppm chlorine dioxide solution (Ciderm® SP) in managing post-surgical wounds in dogs. The solution provided effective antisepsis~~, ~~prevented secondary infections~~, ~~and preserved viable tissue, supporting its use in veterinary wound care~~.~~URL:~~ https://~~www~~.~~annexpublishers~~.co/~~full-text~~/~~JVSAH~~/~~403/Surgical~~-~~wound~~-~~management~~-in-~~dogs~~-~~using~~-an-~~improved-stable-chlorine-dioxide-antiseptic-solution.php,~~		# '''''Surgical Wound Management in Dogs using an Improved Stable Chlorine Dioxide Antiseptic Solution,''''' Authors: Chapnick A, Wilkins RJ, Journal: ''Journal of Veterinary Science and Animal Husbandry,'' Year: 2014, Summary: Three clinical case reports demonstrate the efficacy of a 160 ppm chlorine dioxide solution (Ciderm® SP) in managing post-surgical wounds in dogs. The solution provided effective antisepsis, prevented secondary infections, and preserved viable tissue, supporting its use in veterinary wound care.URL: '''https://www.annexpublishers.co/full-text/JVSAH/403/Surgical-wound-management-in-dogs-using-an-improved-stable-chlorine-dioxide-antiseptic-solution.php<nowiki/>,'''
	# '''~~Controlling Microbial Population in Poultry Industry Using Acidic Slightly Acidic Electrolyzed Water~~ and ~~Chlorine Dioxide''': Potential Non-Thermal Food Sanitizer. Poçan, H. B.~~, ~~& Karakaya, M. (2025).~~ ''~~British Poultry Science~~'~~'. Advance online publication. <nowiki>https~~:~~//doi.org/10.1080/00071668.2025~~.~~2455522<~~/~~nowiki~~>		# '''Controlling Microbial Population in Poultry Industry Using Acidic Slightly Acidic Electrolyzed Water and Chlorine Dioxide''': Potential Non-Thermal Food Sanitizer. Poçan, H. B., & Karakaya, M. (2025). ''British Poultry Science''. Advance online publication. [https://doi.org/10.1080/00071668.2025.2455522 '''https://doi.org/10.1080/00071668.2025.2'''455522]

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Mechanism and Efficiency of Chlorine Dioxide Solution: Studies

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Andreas: /* Toxicology studies of Chlorine dioxide */

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Toxicology studies of Chlorine dioxide

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	== Toxicology studies of Chlorine dioxide ==		== Toxicology studies of Chlorine dioxide ==

	#'''Efficacy and Safety Evaluation of a Chlorine Dioxide Solution.''' Ma, J.-W., Huang, B.-S., Hsu, C.-W., Peng, C.-W., Cheng, M.-L., Kao, J.-Y., ... & Wang, W.-H. ''International Journal of Environmental Research and Public Health'', '''14'''(3), 329, 2017. This study demonstrates CDS’s efficient antimicrobial action in humans and animals, with minimal toxicity at low doses, supporting its medical and veterinary applications. [https://pubmed.ncbi.nlm.nih.gov/28327506/] <ref>		#'''Efficacy and Safety Evaluation of a Chlorine Dioxide Solution.''' Ma, J.-W., Huang, B.-S., Hsu, C.-W., Peng, C.-W., Cheng, M.-L., Kao, J.-Y., ... & Wang, W.-H. ''International Journal of Environmental Research and Public Health'', '''14'''(3), 329, 2017. This study demonstrates CDS’s efficient antimicrobial action in humans and animals, with minimal toxicity at low doses, supporting its medical and veterinary applications. [https://pubmed.ncbi.nlm.nih.gov/28327506/] <ref> '''https://pubmed.ncbi.nlm.nih.gov/28327506/'''
	# '''Toxicological Profile of Chlorine Dioxide and Chlorite.''' Agency for Toxic Substances and Disease Registry. ''U.S. Department of Health and Human Services'', 2004. This report supports CDS’s efficient use in humans and animals by defining safe exposure levels for medical and veterinary applications. [https://atsdr.cdc.gov/toxprofiles/tp160.pdf] <ref>		# '''Toxicological Profile of Chlorine Dioxide and Chlorite.''' Agency for Toxic Substances and Disease Registry. ''U.S. Department of Health and Human Services'', 2004. This report supports CDS’s efficient use in humans and animals by defining safe exposure levels for medical and veterinary applications. [https://atsdr.cdc.gov/toxprofiles/tp160.pdf] <ref> '''https://atsdr.cdc.gov/toxprofiles/tp160.pdf'''
	# '''On the Kinetics and Mechanism of Bacterial Disinfection by Chlorine Dioxide.''' Benarde, M. A., Snow, W. B., Olivieri, V. P., & Moore, B. ''Applied Microbiology'', '''15'''(2), 257–265, 1967. This study highlights CDS’s rapid bacterial disinfection, enhancing its efficiency for infection control in both human and animal contexts. [https://journals.asm.org/doi/10.1128/am.15.2.257-265.1967] <ref>		# '''On the Kinetics and Mechanism of Bacterial Disinfection by Chlorine Dioxide.''' Benarde, M. A., Snow, W. B., Olivieri, V. P., & Moore, B. ''Applied Microbiology'', '''15'''(2), 257–265, 1967. This study highlights CDS’s rapid bacterial disinfection, enhancing its efficiency for infection control in both human and animal contexts. [https://journals.asm.org/doi/10.1128/am.15.2.257-265.1967] <ref> '''https://journals.asm.org/doi/10.1128/am.15.2.257-265.1967'''
	# '''Demonstration of the Safety of Oral Ingestion of Chlorine Dioxide and Its Metabolites, Chlorite and Chlorate.''' Lubbers, J. R., Chauhan, S., & Bianchine, J. R. ''Environmental Health Perspectives'', '''46''', 57–62, 1982. This study confirms CDS’s efficient and safe oral use in humans at low doses, with implications for animal safety. [https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/] <ref>		# '''Demonstration of the Safety of Oral Ingestion of Chlorine Dioxide and Its Metabolites, Chlorite and Chlorate.''' Lubbers, J. R., Chauhan, S., & Bianchine, J. R. ''Environmental Health Perspectives'', '''46''', 57–62, 1982. This study confirms CDS’s efficient and safe oral use in humans at low doses, with implications for animal safety. [https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/] <ref> '''https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/'''
	# '''Toxicological Review of Chlorine Dioxide and Chlorite.''' U.S. Environmental Protection Agency. ''Integrated Risk Information System'', 2000. This comprehensive review provides safety data for CDS, supporting its efficient use in various applications, including animal health. [https://iris.epa.gov/static/pdfs/0496_summary.pdf] <ref>		# '''Toxicological Review of Chlorine Dioxide and Chlorite.''' U.S. Environmental Protection Agency. ''Integrated Risk Information System'', 2000. This comprehensive review provides safety data for CDS, supporting its efficient use in various applications, including animal health. [https://iris.epa.gov/static/pdfs/0496_summary.pdf] <ref> '''https://iris.epa.gov/static/pdfs/0496_summary.pdf'''
	# '''Chlorine Dioxide (ClO2) as a Non-Toxic Antimicrobial Agent for Virus, Bacteria, and Yeast (Candida Albicans).''' ''International Journal of Vaccines & Vaccination'', '''3'''(2), 00052, 2016. This study confirms CDS’s efficient, non-toxic antimicrobial action against pathogens relevant to human and animal health. [~~http~~://medcraveonline.com/IJVV/~~chlorine~~-~~dioxide~~-~~clo2-as-a-non-toxic-antimicrobial-agent-for-virus-bacteria-and-yeast-candida-albicans~~.~~html~~] <ref>		# '''Chlorine Dioxide (ClO2) as a Non-Toxic Antimicrobial Agent for Virus, Bacteria, and Yeast (Candida Albicans).''' ''International Journal of Vaccines & Vaccination'', '''3'''(2), 00052, 2016. This study confirms CDS’s efficient, non-toxic antimicrobial action against pathogens relevant to human and animal health. [https://medcraveonline.com/IJVV/IJVV-02-00052.pdf] <ref> '''https://medcraveonline.com/IJVV/IJVV-02-00052.pdf'''
	# '''Toxicological Profile of Chlorine Dioxide and Chlorite.''' Agency for Toxic Substances and Disease Registry. ''U.S. Department of Health and Human Services'', 2004. This report supports CDS’s efficient use in humans by defining safe exposure levels for medical applications. [https://atsdr.cdc.gov/toxprofiles/tp160.pdf]</ref> <ref>		# '''Toxicological Profile of Chlorine Dioxide and Chlorite.''' Agency for Toxic Substances and Disease Registry. ''U.S. Department of Health and Human Services'', 2004. This report supports CDS’s efficient use in humans by defining safe exposure levels for medical applications. [https://atsdr.cdc.gov/toxprofiles/tp160.pdf]</ref> <ref> '''https://atsdr.cdc.gov/toxprofiles/tp160.pdf'''
	# '''Toxicological Review of Chlorine Dioxide and Chlorite.''' U.S. Environmental Protection Agency. ''Integrated Risk Information System'', 2000. This review confirms CDS’s efficient safety profile for human and animal exposure, supporting its disinfectant efficacy. [https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0496tr.pdf]</ref> <ref>		# '''Toxicological Review of Chlorine Dioxide and Chlorite.''' U.S. Environmental Protection Agency. ''Integrated Risk Information System'', 2000. This review confirms CDS’s efficient safety profile for human and animal exposure, supporting its disinfectant efficacy. [https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0496tr.pdf]</ref> <ref> '''https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0496tr.pdf'''
	# '''Toxicity of Chlorine Dioxide and Chlorite.''' P. Campra F. ''University of Almeria Report'', 2020. This report confirms CDS’s efficient safety at low doses for human medical use, minimizing toxicity risks. DOI:10.13140/RG.2.2.22125.20967 [https://www.researchgate.net/publication/344876982_TOXICIDAD_DEL_DIOXIDO_DE_CLORO_Y_DEL_CLORITO]</ref> <ref>		# '''Toxicity of Chlorine Dioxide and Chlorite.''' P. Campra F. ''University of Almeria Report'', 2020. This report confirms CDS’s efficient safety at low doses for human medical use, minimizing toxicity risks. DOI:10.13140/RG.2.2.22125.20967 [https://www.researchgate.net/publication/344876982_TOXICIDAD_DEL_DIOXIDO_DE_CLORO_Y_DEL_CLORITO]</ref> <ref> '''https://www.researchgate.net/publication/344876982_TOXICIDAD_DEL_DIOXIDO_DE_CLORO_Y_DEL_CLORITO'''
	# '''Six-Month Low-Level Chlorine Dioxide Gas Inhalation Toxicity Study With Two-Week Recovery Period in Rats.''' Akamatsu, A., Lee, C., Morino, H., Miura, T., Ogata, N., & Shibata, T. ''Journal of Occupational Medicine and Toxicology'', '''7'''(1), 2, 2012. This animal study shows CDS gas’s efficient and safe antimicrobial action at 0.1 ppm in rats, supporting human and veterinary infection control. [https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-7-2]</ref> <ref>		# '''Six-Month Low-Level Chlorine Dioxide Gas Inhalation Toxicity Study With Two-Week Recovery Period in Rats.''' Akamatsu, A., Lee, C., Morino, H., Miura, T., Ogata, N., & Shibata, T. ''Journal of Occupational Medicine and Toxicology'', '''7'''(1), 2, 2012. This animal study shows CDS gas’s efficient and safe antimicrobial action at 0.1 ppm in rats, supporting human and veterinary infection control. [https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-7-2]</ref> <ref> '''https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-7-2'''

	== Animal related studies ==		== Animal related studies ==

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References in Human and related

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References in Human and related

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References in Human and related

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Andreas: /* Mechanism and Efficiency of Chlorine Dioxide Solution: Studies */

2025-05-18T12:19:07Z

Mechanism and Efficiency of Chlorine Dioxide Solution: Studies

← Older revision		Revision as of 12:19, 18 May 2025
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	#'''Pharmacokinetics and pharmacodynamics of chlorine dioxide''' ( Original Esp.) Farmacocinética y farmacodinamia del dióxido de cloroAlberto Rubio-Casillas, Pablo Campra-Madrid DOI: https://doi.org/10.32870/ecucba.vi16.202		#'''Pharmacokinetics and pharmacodynamics of chlorine dioxide''' ( Original Esp.) Farmacocinética y farmacodinamia del dióxido de cloroAlberto Rubio-Casillas, Pablo Campra-Madrid DOI: https://doi.org/10.32870/ecucba.vi16.202
	#'''Effect of chlorine dioxide in the prevention of adhesion formation in pelvic surgery.''' (orginal Esp.) Efecto del dióxido de cloro en la prevención de la formación de adherencias en cirugía pélvica".Mancera Andrade, Jose. (2014). (Trabajo de grado de especialización). Universidad Nacional Autónoma de México, México. Recuperado de https://repositorio.unam.mx/contenidos/380887		#'''Effect of chlorine dioxide in the prevention of adhesion formation in pelvic surgery.''' (orginal Esp.) Efecto del dióxido de cloro en la prevención de la formación de adherencias en cirugía pélvica".Mancera Andrade, Jose. (2014). (Trabajo de grado de especialización). Universidad Nacional Autónoma de México, México. Recuperado de https://repositorio.unam.mx/contenidos/380887
	#Patient-reported health outcomes after treatment of covid-19 with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care versus usual medical care alone: a randomized, open-label, controlled trial. Delgado‐Enciso, I., Paz-García, J., Barajas-Saucedo, C. E., Mokay-Ramírez, K. A., Meza‐Robles, C., Lopez‐Flores, R., … & Paz-Michel, B. (2020). <nowiki>https://doi.org/10.21203/rs.3.rs-68403/v1</nowiki> https://www.researchsquare.com/article/rs-68403/v1		#'''Patient-reported health outcomes after treatment of covid-19 with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care versus usual medical care alone: a randomized, open-label, controlled trial.''' Delgado‐Enciso, I., Paz-García, J., Barajas-Saucedo, C. E., Mokay-Ramírez, K. A., Meza‐Robles, C., Lopez‐Flores, R., … & Paz-Michel, B. (2020). <nowiki>https://doi.org/10.21203/rs.3.rs-68403/v1</nowiki> https://www.researchsquare.com/article/rs-68403/v1
	#Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man. Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027.		#'''Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.''' Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027. https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657
			#A'''ctivated Chlorine Dioxide Solution Can Be Used as a Biocompatible Antiseptic Wound Irrigant,''' Valente, Jonathan H. MD; Jay, Gregory D. MD, PhD; Zabbo, Christopher P. DO; Reinert, Steven E. MS; Bertsch, Karina MSW doi: 10.1097/01.ASW.0000439060.79822.b3. https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx

	== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==		== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==

Andreas: /* Toxicology studies of Chlorine dioxide */

2025-05-12T21:48:10Z

Toxicology studies of Chlorine dioxide

← Older revision		Revision as of 21:48, 12 May 2025
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	#'''Impact of Chlorine Dioxide on Pathogenic Waterborne Microorganisms Occurring in Dental Chair Units'''. Krüger, T.I.M.; Herzog, S.; Mellmann, A.; Kuczius, T.Microorganisms 2023, 11, 1123. <nowiki>https://doi.org/10.3390/microorganisms11051123</nowiki> https://www.mdpi.com/2076-2607/11/5/1123		#'''Impact of Chlorine Dioxide on Pathogenic Waterborne Microorganisms Occurring in Dental Chair Units'''. Krüger, T.I.M.; Herzog, S.; Mellmann, A.; Kuczius, T.Microorganisms 2023, 11, 1123. <nowiki>https://doi.org/10.3390/microorganisms11051123</nowiki> https://www.mdpi.com/2076-2607/11/5/1123
	#'''Evaluation of ultrasonic scaling unit waterline contamination after use of chlorine dioxide mouthrinse lavage'''.Wirthlin MR, Marshall GW JR. J Periodontol. 2001 Mar;72(3):401-10. doi: 10.1902/jop.2001.72.3.401. PMID: 11327069.https://aap.onlinelibrary.wiley.com/doi/10.1902/jop.2001.72.3.401		#'''Evaluation of ultrasonic scaling unit waterline contamination after use of chlorine dioxide mouthrinse lavage'''.Wirthlin MR, Marshall GW JR. J Periodontol. 2001 Mar;72(3):401-10. doi: 10.1902/jop.2001.72.3.401. PMID: 11327069.https://aap.onlinelibrary.wiley.com/doi/10.1902/jop.2001.72.3.401
			#'''Elimination of Legionella Colonization in a Hospital Water System: Evidence from 23 Years of Chlorine Dioxide''' Use. Exum, N. G., Avolio, L. N., Bova, G., Rock, C., Curless, M. S., Maragakis, L. L., & Schwab, K. J. (2025). ''Infection Control & Hospital Epidemiology'', 46(4), 1-3. <nowiki>https://doi.org/10.1017/ice.2025.25</nowiki>
			#'''Transcriptomic Analysis of Campylobacter jejuni Following Exposure to Gaseous Chlorine Dioxide Reveals Oxidative Stress Response'''. Dykes, G. E., He, Y., Jin, T., Fan, X., Lee, J., Reed, S., & Capobianco, J. (2025). . ''International Journal of Molecular Sciences'', 26(7), 3254. <nowiki>https://doi.org/10.3390/ijms26073254</nowiki>
			#

	== Toxicology studies of Chlorine dioxide ==		== Toxicology studies of Chlorine dioxide ==
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	# '''Effects of dietary chlorine dioxide on growth performance, intestinal and excreta microbiology, and odorous gas emissions from broiler excreta,''' Authors: Ahmed ST, Kim G, Islam MM, Mun HS, Bostami ABM,Journal: Journal of Applied Poultry Research, Year: 2015,Volume: 24(4),Pages: 502-510 https://www.pvj.com.pk/pdf-files/35_2/183-187.pdf		# '''Effects of dietary chlorine dioxide on growth performance, intestinal and excreta microbiology, and odorous gas emissions from broiler excreta,''' Authors: Ahmed ST, Kim G, Islam MM, Mun HS, Bostami ABM,Journal: Journal of Applied Poultry Research, Year: 2015,Volume: 24(4),Pages: 502-510 https://www.pvj.com.pk/pdf-files/35_2/183-187.pdf
	# '''''Surgical Wound Management in Dogs using an Improved Stable Chlorine Dioxide Antiseptic Solution,''''' Authors: Chapnick A, Wilkins RJ, Journal: ''Journal of Veterinary Science and Animal Husbandry,'' Year: 2014, Summary: Three clinical case reports demonstrate the efficacy of a 160 ppm chlorine dioxide solution (Ciderm® SP) in managing post-surgical wounds in dogs. The solution provided effective antisepsis, prevented secondary infections, and preserved viable tissue, supporting its use in veterinary wound care.URL: https://www.annexpublishers.co/full-text/JVSAH/403/Surgical-wound-management-in-dogs-using-an-improved-stable-chlorine-dioxide-antiseptic-solution.php,		# '''''Surgical Wound Management in Dogs using an Improved Stable Chlorine Dioxide Antiseptic Solution,''''' Authors: Chapnick A, Wilkins RJ, Journal: ''Journal of Veterinary Science and Animal Husbandry,'' Year: 2014, Summary: Three clinical case reports demonstrate the efficacy of a 160 ppm chlorine dioxide solution (Ciderm® SP) in managing post-surgical wounds in dogs. The solution provided effective antisepsis, prevented secondary infections, and preserved viable tissue, supporting its use in veterinary wound care.URL: https://www.annexpublishers.co/full-text/JVSAH/403/Surgical-wound-management-in-dogs-using-an-improved-stable-chlorine-dioxide-antiseptic-solution.php,
			# '''Controlling Microbial Population in Poultry Industry Using Acidic Slightly Acidic Electrolyzed Water and Chlorine Dioxide''': Potential Non-Thermal Food Sanitizer. Poçan, H. B., & Karakaya, M. (2025). ''British Poultry Science''. Advance online publication. <nowiki>https://doi.org/10.1080/00071668.2025.2455522</nowiki>

← Older revision		Revision as of 17:32, 14 October 2025
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	# '''Eradication of Borrelia Burgdorferi In Vitro Using Chlorine Dioxide: A Novel Approach.''' George Georgiou, ''Medical Research Archives'', '''10'''(10), 2022. This in vitro study suggests CDS’s efficient eradication of Borrelia burgdorferi, supporting potential treatments for Lyme disease in humans and animals. [https://esmed.org/MRA/mra/article/view/3279/193546488] <ref> '''https://esmed.org/MRA/mra/article/view/3279/193546488'''		# '''Eradication of Borrelia Burgdorferi In Vitro Using Chlorine Dioxide: A Novel Approach.''' George Georgiou, ''Medical Research Archives'', '''10'''(10), 2022. This in vitro study suggests CDS’s efficient eradication of Borrelia burgdorferi, supporting potential treatments for Lyme disease in humans and animals. [https://esmed.org/MRA/mra/article/view/3279/193546488] <ref> '''https://esmed.org/MRA/mra/article/view/3279/193546488'''
	# '''Orphan Designation by the European Medicines Agency (EMA) for NaClO2 (Sodium Chlorite) as a Treatment for Amyotrophic Lateral Sclerosis (ALS).''' European Medicines Agency. ''EMA Orphan Designations'', 2013. This designation highlights sodium chlorite’s (CDS precursor) efficient potential for ALS treatment in humans, with broader implications for neurological conditions in animals. [https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-13-1139] <ref> '''https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-13-1139'''		# '''Orphan Designation by the European Medicines Agency (EMA) for NaClO2 (Sodium Chlorite) as a Treatment for Amyotrophic Lateral Sclerosis (ALS).''' European Medicines Agency. ''EMA Orphan Designations'', 2013. This designation highlights sodium chlorite’s (CDS precursor) efficient potential for ALS treatment in humans, with broader implications for neurological conditions in animals. [https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-13-1139] <ref> '''https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu-3-13-1139'''
	# '''Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial.''' Yeturu, S.K.; Acharya, S.; Urala, A.S.; Pentapati, K.C. ''J. Oral Biol. Craniofac. Res.'' '''2016''',. [[https://www.sciencedirect.com/science/article/abs/pii/S2212426815000913?via%3Dihub 53]]		# '''Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial.''' Yeturu, S.K.; Acharya, S.; Urala, A.S.; Pentapati, K.C. ''J. Oral Biol. Craniofac. Res.'' '''2016''',. [[https://www.sciencedirect.com/science/article/abs/pii/S2212426815000913?via%3Dihub 53]] '''https://www.sciencedirect.com/science/article/abs/pii/S2212426815000913?via%3Dihub'''
	# '''Protective effect of low-concentration chlorine dioxide gas against influenza a virus infection.''' Ogata N., Shibata T. J. Gen. Virol. 2008;89:60–67. doi: 10.1099/vir.0.83393-0. - DOI - PubMed [[https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83393-0 54]]		# '''Protective effect of low-concentration chlorine dioxide gas against influenza a virus infection.''' Ogata N., Shibata T. J. Gen. Virol. 2008;89:60–67. doi: 10.1099/vir.0.83393-0. - DOI - PubMed [[https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83393-0 54]] '''https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83393-0'''
	# '''Demonstration of the Safety of Oral Ingestion of Chlorine Dioxide and Its Metabolites, Chlorite and Chlorate.''' Lubbers, J. R., Chauhan, S., & Bianchine, J. R. ''Environmental Health Perspectives'', '''46''', 57–62, 1982. This study confirms CDS’s efficient and safe oral use in humans at low doses, enabling therapeutic applications. [https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/]</ref> <ref>		# '''Demonstration of the Safety of Oral Ingestion of Chlorine Dioxide and Its Metabolites, Chlorite and Chlorate.''' Lubbers, J. R., Chauhan, S., & Bianchine, J. R. ''Environmental Health Perspectives'', '''46''', 57–62, 1982. This study confirms CDS’s efficient and safe oral use in humans at low doses, enabling therapeutic applications. [https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/]</ref> <ref> '''https://pmc.ncbi.nlm.nih.gov/articles/PMC1569027/'''
	# '''Effects of Acute Administration of Increasing Doses of Chlorine Dioxide, Chlorate, and Chlorite in Humans.''' Lubbers, J. R., Chauhan, S., Miller, J. K., & Bianchine, J. R. ''Journal of Environmental Pathology, Toxicology and Oncology'', '''5'''(4–5), 229–238, 1984. This study verifies CDS’s efficient safety profile in humans, with effective doses showing minimal adverse effects. [https://pubmed.ncbi.nlm.nih.gov/6520727/]</ref> <ref>		# '''Effects of Acute Administration of Increasing Doses of Chlorine Dioxide, Chlorate, and Chlorite in Humans.''' Lubbers, J. R., Chauhan, S., Miller, J. K., & Bianchine, J. R. ''Journal of Environmental Pathology, Toxicology and Oncology'', '''5'''(4–5), 229–238, 1984. This study verifies CDS’s efficient safety profile in humans, with effective doses showing minimal adverse effects. [https://pubmed.ncbi.nlm.nih.gov/6520727/]</ref> <ref> '''https://pubmed.ncbi.nlm.nih.gov/6520727/'''
	# '''Effects of Chlorine Dioxide on Oral Hygiene: A Systematic Review and Meta-Analysis.''' Kerényi, M., Nagy, A., & Székely, J. ''Current Pharmaceutical Design'', '''26'''(32), 4105–4114, 2020. This review confirms CDS’s efficient antimicrobial action in human oral hygiene, reducing pathogens effectively. [https://www.eurekaselect.com/article/106659]</ref> <ref>		# '''Effects of Chlorine Dioxide on Oral Hygiene: A Systematic Review and Meta-Analysis.''' Kerényi, M., Nagy, A., & Székely, J. ''Current Pharmaceutical Design'', '''26'''(32), 4105–4114, 2020. This review confirms CDS’s efficient antimicrobial action in human oral hygiene, reducing pathogens effectively. [https://www.eurekaselect.com/article/106659]</ref> <ref> https://www.eurekaselect.com/article/106659
	#'''Eradication of Antibiotic-Resistant E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A. baumannii, and P. aeruginosa With Chlorine Dioxide In Vitro.''' George Georgiou, Agnieszka Kotzé ''Medical Research Archives'', '''11'''(8), 2023. This study demonstrates CDS’s efficient eradication of antibiotic-resistant bacteria, relevant to human infections. [https://esmed.org/MRA/mra/article/view/4218/99193547165]</ref> <ref>		#'''Eradication of Antibiotic-Resistant E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A. baumannii, and P. aeruginosa With Chlorine Dioxide In Vitro.''' George Georgiou, Agnieszka Kotzé ''Medical Research Archives'', '''11'''(8), 2023. This study demonstrates CDS’s efficient eradication of antibiotic-resistant bacteria, relevant to human infections. [https://esmed.org/MRA/mra/article/view/4218/99193547165]</ref> <ref> '''https://esmed.org/MRA/mra/article/view/4218/99193547165'''
	#'''Opportunistic Infection Induced by Stress and Silent Type 2 Diabetes Mellitus in Young Adult Patient: A Case Report.''' Karina D, Heldayani I, Hidayat W. Oral Int Med Case Rep J. 2025 Jan 11;18:59-66. doi: 10.2147/IMCRJ.S488127. PMID: 39822734; PMCID: PMC11735534.https://www.dovepress.com/oral-opportunistic-infection-induced-by-stress-and-silent-type-2-diabe-peer-reviewed-fulltext-article-IMCRJ		#'''Opportunistic Infection Induced by Stress and Silent Type 2 Diabetes Mellitus in Young Adult Patient: A Case Report.''' Karina D, Heldayani I, Hidayat W. Oral Int Med Case Rep J. 2025 Jan 11;18:59-66. doi: 10.2147/IMCRJ.S488127. PMID: 39822734; PMCID: PMC11735534. '''https://www.dovepress.com/oral-opportunistic-infection-induced-by-stress-and-silent-type-2-diabe-peer-reviewed-fulltext-article-IMCRJ'''
	#'''Pharmacokinetics and pharmacodynamics of chlorine dioxide''' ( Original Esp.) Farmacocinética y farmacodinamia del dióxido de cloroAlberto Rubio-Casillas, Pablo Campra-Madrid DOI: https://~~doi~~.org/~~10.32870~~/~~ecucba.vi16.202~~		#'''Pharmacokinetics and pharmacodynamics of chlorine dioxide''' ( Original Esp.) Farmacocinética y farmacodinamia del dióxido de cloroAlberto Rubio-Casillas, Pablo Campra-Madrid DOI: '''https://esmed.org/MRA/mra/article/view/4218/99193547165'''
	#'''Effect of chlorine dioxide in the prevention of adhesion formation in pelvic surgery.''' (orginal Esp.) Efecto del dióxido de cloro en la prevención de la formación de adherencias en cirugía pélvica".Mancera Andrade, Jose. (2014). (Trabajo de grado de especialización). Universidad Nacional Autónoma de México, México. Recuperado de https://repositorio.unam.mx/contenidos/380887		#'''Effect of chlorine dioxide in the prevention of adhesion formation in pelvic surgery.''' (orginal Esp.) Efecto del dióxido de cloro en la prevención de la formación de adherencias en cirugía pélvica".Mancera Andrade, Jose. (2014). (Trabajo de grado de especialización). Universidad Nacional Autónoma de México, México. Recuperado de https://repositorio.unam.mx/contenidos/380887'''https://repositorio.unam.mx/contenidos/380887'''
	#'''Patient-reported health outcomes after treatment of covid-19 with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care versus usual medical care alone: a randomized, open-label, controlled trial.''' Delgado‐Enciso, I., Paz-García, J., Barajas-Saucedo, C. E., Mokay-Ramírez, K. A., Meza‐Robles, C., Lopez‐Flores, R., … & Paz-Michel, B. (2020). <nowiki>https://doi.org/10.21203/rs.3.rs-68403/v1</nowiki> https://www.researchsquare.com/article/rs-68403/v1		#'''Patient-reported health outcomes after treatment of covid-19 with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care versus usual medical care alone: a randomized, open-label, controlled trial.''' Delgado‐Enciso, I., Paz-García, J., Barajas-Saucedo, C. E., Mokay-Ramírez, K. A., Meza‐Robles, C., Lopez‐Flores, R., … & Paz-Michel, B. (2020). <nowiki>https://doi.org/10.21203/rs.3.rs-68403/v1</nowiki> https://www.researchsquare.com/article/rs-68403/v1'''https://www.researchsquare.com/article/rs-68403/v1'''
	#'''Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.''' Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027. https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657		#'''Lubbers JR, Chauan S, Bianchine JR. Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.''' Environ Health Perspect. 1982 Dec;46:57-62. doi: 10.1289/ehp.824657. PMID: 6961033; PMCID: PMC1569027. https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''https://ehp.niehs.nih.gov/doi/10.1289/ehp.824657'''
	#A'''ctivated Chlorine Dioxide Solution Can Be Used as a Biocompatible Antiseptic Wound Irrigant,''' Valente, Jonathan H. MD; Jay, Gregory D. MD, PhD; Zabbo, Christopher P. DO; Reinert, Steven E. MS; Bertsch, Karina MSW doi: 10.1097/01.ASW.0000439060.79822.b3. https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx		#A'''ctivated Chlorine Dioxide Solution Can Be Used as a Biocompatible Antiseptic Wound Irrigant,''' Valente, Jonathan H. MD; Jay, Gregory D. MD, PhD; Zabbo, Christopher P. DO; Reinert, Steven E. MS; Bertsch, Karina MSW doi: 10.1097/01.ASW.0000439060.79822.b3. https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''https://journals.lww.com/aswcjournal/abstract/2014/01000/activated_chlorine_dioxide_solution_can_be_used_as.6.aspx'''

	== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==		== Mechanism and Efficiency of Chlorine Dioxide Solution: Studies ==