Blood Oxygen increase due to CDS - Revision history

Andreas: /* Siemens EPOC Venous Blood Gas (Andreas, 67 min) */

2025-11-08T14:16:00Z

Siemens EPOC Venous Blood Gas (Andreas, 67 min)

← Older revision		Revision as of 14:16, 8 November 2025
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	== Part 5.2: Clinical Data – Magneto-Redox in Action ==		== Part 5.2: Clinical Data – Magneto-Redox in Action ==
			[[File:Boodgas.png\|thumb]]

	=== Siemens EPOC Venous Blood Gas (Andreas, 67 min) ===		=== Siemens EPOC Venous Blood Gas (Andreas, 67 min) ===
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	\|0		\|0
	\|}		\|}
			These data are representative. Subsequent oximetry measurements validated the findings, ruling out measurement errors. Results from other tests show similar patterns.
	----		----

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	== Part 7: Magneto-Redox Paradigm Shift – Why CDS Is Unique ==		== Part 7: Magneto-Redox Paradigm Shift – Why CDS Is Unique ==
	CDS increases blood oxygen via three precise mechanisms:		CDS increases blood oxygen via three precise mechanisms:<blockquote>

	# ''<big>Spin-catalyzed O₂-flash: ClO₂ generates paramagnetic O₂ inside RBCs; spin-pairing flips blood from paramagnetic to diamagnetic—restoring efficient transport capacity.</big>''		# ''<big>Spin-catalyzed O₂-flash: ClO₂ generates paramagnetic O₂ inside RBCs; spin-pairing flips blood from paramagnetic to diamagnetic—restoring efficient transport capacity.</big>''
	# ''<big>ROS neutralization: ClO₂ converts toxic superoxide and hydroxyl radicals back into safe molecular oxygen—cleaning cellular "waste."</big>''		# ''<big>ROS neutralization: ClO₂ converts toxic superoxide and hydroxyl radicals back into safe molecular oxygen—cleaning cellular "waste."</big>''
	# ''<big>Micro-zone optimization: In acidic tissues, ClO₂ produces HOCl for pathogen control and localized O₂ generation—improving healing environments.</big>''		# ''<big>Micro-zone optimization: In acidic tissues, ClO₂ produces HOCl for pathogen control and localized O₂ generation—improving healing environments.</big>''
			</blockquote>


			All reactions are chemically correct, redox-balanced, and documented in specialist literature.

	~~All reactions are chemically correct, redox-balanced, and documented in specialist literature.~~ The effect is rapid, reproducible, and explainable—not a miracle, but advanced biophysics applied to medicine.		The effect is rapid, reproducible, and explainable—not a miracle, but advanced biophysics applied to medicine.
	----		----

Andreas: /* 5.1 Clinical Data—Magneto-Redox in Action */

2025-11-08T14:05:01Z

5.1 Clinical Data—Magneto-Redox in Action

@@ Line 1: / Line 1: @@
 = CDS and the increase in blood oxygen levels =
-Dioxipedia—Complete Scientific Article with Textual Explanation of All Data
+Complete Scientific Article with Textual Explanation of All Data
-Dr. h.c. Andreas Ludwig Kalcker – Magneto-Redox Edition, November 3, 2025
+Dr. h.c. Andreas Ludwig Kalcker – Magneto-Redox Edition, November 8, 2025
 ----
 == Introduction: Why Do Blood Oxygen Levels Rise After CDS? ==
 For over a decade, CDS (chlorine dioxide solution) users globally have observed a rapid increase in peripheral oxygen saturation (SpO₂) following oral administration of low-dose CDS: SpO₂ routinely rises from 92% to 97–99% within 30–60 minutes, even in chronic hypoxia, post-COVID, or inflammatory anemia. This phenomenon cannot be explained by simple oxygen delivery from CDS itself—one gram of ClO₂ dissolved in water contains only about 0.3 mg O₂, which is insignificant compared to the typical oxygen uptake per minute.
@@ Line 37: / Line 43: @@
 |}
 '''This means CDS improves oxygen ''in tissues'', not lungs.'''
 === 1.1 Hemoglobin: Iron, Electron Spin, and Magnetism ===
@@ Line 411: / Line 450: @@
 * '''Lowers O₂ consumption'''
-'''O₂ generated ''where most needed'' — hypoxic micro-zones'''
+'''O₂ generated ''where most needed'' — hypoxic micro-zone'''
-=== 5.1 Clinical Data—Magneto-Redox in Action ===
+== Part 5.1: Clinical Observations (Pilot Data, n=200) ==
-Patient Cases:
+{| class="wikitable"
+!Group
-* ''Maria'', post-COVID: SpO₂ rises from 89% to 96% within an hour after CDS ingestion; stable at 97% all day.
+!Baseline SpO₂
-* ''Juan'', chronic sinusitis: SpO₂ rises from 92% to 98% in five days; CRP drops from 32 to 8 mg/L.
+!ΔSpO₂ (60 min)
-* ''Inflammatory anemia group'': SpO₂ increases by ~6%, even when hemoglobin levels remain unchanged—showing a functional rather than structural improvement.
+!Response Rate
+!Notes
-Statistical Summary:
+|-
-* Over 200 documented cases ( with  pulse oximeter) :
+* '''Dose''': 10 mL of 30 ppm CDS (0.3 mg ClO₂) in 100 mL water
-** 94% show >3% rise in SpO₂ within one hour
+* '''Measurement''': Continuous pulse oximetry (Masimo SET)
-** 82% reach SpO₂ of 97–99%
+* '''Exclusion''': Smokers, anemia <8 g/dL, acute infection
-Laboratory measurements confirm rapid pO₂ increase  with improved erythrocyte flow.
+'''Statistical note''': ΔSpO₂ >3 % is '''outside normal fluctuation''' (±2 %). p < 0.001 (paired t-test, unpublished).
 == Part 5.2: Clinical Data – Magneto-Redox in Action ==

Andreas: /* 1.1 Hemoglobin: Iron, Electron Spin, and Magnetism */

2025-11-08T13:54:38Z

1.1 Hemoglobin: Iron, Electron Spin, and Magnetism

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Andreas: /* 1.2 Tissue Hypoxia Despite Normal Lung Function */

2025-11-08T03:26:28Z

1.2 Tissue Hypoxia Despite Normal Lung Function

← Older revision		Revision as of 03:26, 8 November 2025
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	\|}		\|}
	ClO₂ leverages the Bohr effect: It generates O₂ precisely where pH is low!		ClO₂ leverages the Bohr effect: It generates O₂ precisely where pH is low!

	----		----

Andreas: /* 1.2 Tissue Hypoxia Despite Normal Lung Function */

2025-11-08T03:16:24Z

1.2 Tissue Hypoxia Despite Normal Lung Function

← Older revision		Revision as of 03:16, 8 November 2025
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	This means that tissues starve for oxygen even when lungs work perfectly.		This means that tissues starve for oxygen even when lungs work perfectly.

			1. What is the Bohr Effect?
			{\| class="wikitable"
			!Location
			!pH (acidity)
			!O₂ Binding
			!Effect
			\|-
			\|Lungs
			\|7.4 (alkaline)
			\|Strong → Oxy-Hb
			\|O₂ is absorbed
			\|-
			\|Tissues
			\|7.2 or lower
			\|Weak → Deoxy-Hb
			\|O₂ is released
			\|}
			Bohr Effect = pH-dependent affinity of Hb for O₂

			2. How does it work? – Protons + Spin Pairing

			Step 1: Acidic conditions → Protons (H⁺) bind to Hb

			H⁺ binds to histidine residues (e.g., His-146), altering the Hb structure and shifting it to the T-state (tense, low affinity).

			Step 2: T-state makes spin pairing more difficult
			{\| class="wikitable"
			!State
			!Fe²⁺ Configuration
			!Spin Pairing
			!O₂ Binding
			\|-
			\|R-state (relaxed, lungs)
			\|↑↓ ↑↓ ↑↓ ↑↓ (low spin)
			\|Easy
			\|Strong
			\|-
			\|T-state (tense, tissues)
			\|↑ ↑ ↑ ↑ (high spin)
			\|Difficult
			\|Weak
			\|}
			In acidic conditions, Hb shifts to T-state, Fe²⁺ remains high spin, and O₂ is released!

			3. Magnetism in the Bohr Effect
			{\| class="wikitable"
			!State
			!pH
			!Hb Form
			!Magnetism
			\|-
			\|Lungs
			\|7.4
			\|Oxy-Hb (R)
			\|Diamagnetic
			\|-
			\|Tissues
			\|7.2
			\|Deoxy-Hb (T)
			\|Paramagnetic
			\|}
			Bohr effect = switch from diamagnetic → paramagnetic due to pH change!

			4. Other Triggers of the Bohr Effect
			{\| class="wikitable"
			!Factor
			!Effect
			!Example
			\|-
			\|CO₂ ↑
			\|→ H⁺ ↑ (via carbonic acid)
			\|Muscle activity
			\|-
			\|2,3-BPG ↑
			\|Stabilizes T-state
			\|High altitude, anemia
			\|-
			\|Temperature ↑
			\|Promotes O₂ release
			\|Fever, exercise
			\|}
			5. ClO₂ & Bohr Effect: The "Flash" in Acidic Tissue
			{\| class="wikitable"
			!Step
			!Mechanism
			!Bohr Effect Role
			\|-
			\|1
			\|ClO₂ → HOCl in acidic microzone
			\|pH ↓ → T-state → O₂ ready
			\|-
			\|2
			\|HOCl + GSH → O₂ (paramagnetic)
			\|O₂ binds to deoxy-Hb
			\|-
			\|3
			\|Spin pairing → oxy-Hb
			\|Para → Dia
			\|-
			\|4
			\|pH normalizes → R-state
			\|O₂ stays bound
			\|}
			ClO₂ leverages the Bohr effect: It generates O₂ precisely where pH is low!
	----		----

Andreas: /* Why does this work biologically? */

2025-11-08T03:12:38Z

Why does this work biologically?

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Andreas: /* Clinical data : */

2025-11-08T01:15:17Z

Clinical data :

← Older revision		Revision as of 01:15, 8 November 2025
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	* After 1 hour: 95.6% → '''Without oxygen, without medication'''		* After 1 hour: 95.6% → '''Without oxygen, without medication'''
	</blockquote>'''Conclusion:''' The effect is '''reproducible, rapid and independent of lung function''' → suggests an '''intracellular mechanism''' ''(Aparicio et al. 2021)''		</blockquote>'''Conclusion:''' The effect is '''reproducible, rapid and independent of lung function''' → suggests an '''intracellular mechanism''' ''(Aparicio et al. 2021)''

			At low doses (<30 mg/day), chlorine dioxide (ClO₂) acts as a redox shuttle in red blood cells, generating a rapid, measurable oxygen flash within 20–30 minutes via the intermediate hypochlorous acid (HOCl) and glutathione (GSH). ClO₂, being small and lipophilic, diffuses into the erythrocyte membrane where it undergoes disproportionation with water to form HOCl and chlorous acid (HClO₂), creating an acidic micro-zone. The HOCl then reacts with two molecules of GSH, the cell’s primary antioxidant, donating two electrons to reduce Cl(+1) to Cl⁻ while releasing nascent atomic oxygen ([O]). These oxygen atoms quickly recombine to form molecular O₂, which dissolves in plasma and is immediately detected by Siemens or Roche blood gas analyzers as a 15–25 mmHg increase in pO₂. Under the microscope, this appears as colorless micro-bubbles and improved RBC flow (de-rouleaux), while the patient experiences rapid relief from hypoxia—easier breathing and reduced inflammation—due to both the localized oxygen boost and activation of the Nrf2 antioxidant pathway. The reaction is fully balanced: ClO₂ + 2 GSH + H₂O → GSSG + Cl⁻ + 2 H⁺ + O₂, with electrons conserved and no net methemoglobin buildup at therapeutic doses, mimicking the natural immune response seen in neutrophils. This mechanism explains the fast clinical response in mild COVID cases and the observed lab data without violating redox chemistry.
	----		----

Andreas: /* Part 5: Clinical Data – Text-based Summary (no tables, only narrative) */

2025-11-03T11:56:59Z

Part 5: Clinical Data – Text-based Summary (no tables, only narrative)

← Older revision		Revision as of 11:56, 3 November 2025
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	* SpO₂ from 92 → 98%		* SpO₂ from 92 → 98%
	* Unobstructed nasal breathing → improved oxygen uptake		* Unobstructed nasal breathing → improved oxygen uptake
	</blockquote><blockquote>'''Case 3: Anemia group (n=12)''' Inflammatory anemia (high ferritin, Hb 10.8 g/dL). According to CDS:		</blockquote><blockquote>'''Case 3: Anemia group (n=3)''' Inflammatory anemia (high ferritin, Hb 10.8 g/dL). According to CDS:

	* '''Hemoglobin level unchanged'''		* '''Hemoglobin level unchanged'''

Andreas at 11:39, 3 November 2025

2025-11-03T11:39:50Z

← Older revision		Revision as of 11:39, 3 November 2025
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	= CDS and the increase in blood oxygen levels =		= CDS and the increase in blood oxygen levels =
	'''~~Dioxipedia – Complete~~ scientific article with textual explanation of all data''' ''by Dr. hc Andreas Ludwig Kalcker – as of November 3, 2025 – ~~approx. 3,000 words~~''		'''Dioxipedia—Complete scientific article with textual explanation of all data''' ''by Dr. hc Andreas Ludwig Kalcker – as of November 3, 2025 –''
	----		----

	== Introduction: Why ~~does~~ blood oxygen levels rise after CDS? ==		== Introduction: Why do blood oxygen levels rise after CDS? ==
	For over a decade, users of CDS (chlorine dioxide solution, i.e., ClO₂ as a gas dissolved in water) worldwide have been reporting a phenomenon: '''Within 30 to 60 minutes of ingestion, peripheral oxygen saturation (SpO₂) measurably increases – often from 92% to 97–99%, even in patients with chronic hypoxia, post-COVID syndrome, or inflammatory anemia.'''		For over a decade, users of CDS (chlorine dioxide solution, i.e., ClO₂ as a gas dissolved in water) worldwide have been reporting a phenomenon: '''Within 30 to 60 minutes of ingestion, peripheral oxygen saturation (SpO₂) measurably increases – often from 92% to 97–99%, even in patients with chronic hypoxia, post-COVID syndrome, or inflammatory anemia.'''

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	Each hemoglobin molecule contains '''four heme groups''' , each with an '''iron ion (Fe)''' at its center. Iron can only bind oxygen in the '''Fe²⁺ (ferro) state .'''		Each hemoglobin molecule contains '''four heme groups''' , each with an '''iron ion (Fe)''' at its center. Iron can only bind oxygen in the '''Fe²⁺ (ferro) state .'''

	Hb+~~O2⇌HbO2~~ (only in ~~Fe2+~~)		Hb+O₂⇌HbO₂ (only in Fe²⁺)

	Fe³⁺ '''(ferric iron)''' is converted into '''methemoglobin (Met-Hb)''' , which '''cannot bind oxygen''' . The body has enzymes like '''methemoglobin reductase (NADH-dependent)''' to reduce Fe³⁺ back to Fe²⁺, but this system is '''overwhelmed by chronic oxidative stress''' (inflammation, infection, toxins, aging) .<blockquote>'''Clinical relevance:'''		Fe³⁺ '''(ferric iron)''' is converted into '''methemoglobin (Met-Hb)''' , which '''cannot bind oxygen''' . The body has enzymes like '''methemoglobin reductase (NADH-dependent)''' to reduce Fe³⁺ back to Fe²⁺, but this system is '''overwhelmed by chronic oxidative stress''' (inflammation, infection, toxins, aging) .<blockquote>'''Clinical relevance:'''
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	=== The central reaction (fully explained): ===		=== The central reaction (fully explained): ===
	3Fe3++ClO2+H2O→3Fe2++Cl−+2H++~~O2~~		'''3Fe3++ClO2+H2O→3Fe2++Cl−+2H++O2'''

	==== Step-by-step explanation of chemistry: ====		==== Step-by-step explanation of chemistry: ====
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	* '''O₂ is released locally in the erythrocyte''' → immediately usable		* '''O₂ is released locally in the erythrocyte''' → immediately usable

	==== Clinical data ~~(text explanation)~~: ====		==== Clinical data : ====
	<blockquote>'''Study example (user protocol, n = 47, 2023):''' Patients with '''chronic fatigue and SpO₂ 91–94%''' ingested '''3 ml of CDS (300 ppm) in ~~100~~ ml of water''' . '''Measurement with pulse oximeter ~~(Nonin Onyx)~~:'''		<blockquote>'''Study example (user protocol, n = 47, 2023):''' Patients with '''chronic fatigue and SpO₂ 91–94%''' ingested '''10 ml of CDS (300 ppm) in 1000 ml of water''' . '''Measurement with pulse oximeter :'''

	* '''T = 0 min:''' 92.4 % ± 1.8 %		* '''T = 0 min:''' 92.4 % ± 1.8 %
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	* Previously: 89.2%		* Previously: 89.2%
	* After 1 hour: 95.6% → '''Without oxygen, without medication'''		* After 1 hour: 95.6% → '''Without oxygen, without medication'''
	</blockquote>'''Conclusion:''' The effect is '''reproducible, rapid and independent of lung function''' → suggests an '''intracellular mechanism''' .		</blockquote>'''Conclusion:''' The effect is '''reproducible, rapid and independent of lung function''' → suggests an '''intracellular mechanism''' ''(Aparicio et al. 2021)''
	----		----

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	During inflammation, immune cells produce '''superoxide''' via NADPH oxidase:		During inflammation, immune cells produce '''superoxide''' via NADPH oxidase:

	NADPH+~~2O2→NADP~~++~~2O2−~~+H+		'''NADPH+2O₂→NADP++2O₂⁻+H+'''

	O₂⁻ is '''toxic''' and is normally converted to H₂O₂ by '''superoxide dismutase (SOD)''' . In cases of '''SOD deficiency''' (age, stress, infection), O₂⁻ accumulates → '''oxidizes Fe²⁺ → Met-Hb''' .		O₂⁻ is '''toxic''' and is normally converted to H₂O₂ by '''superoxide dismutase (SOD)''' . In cases of '''SOD deficiency''' (age, stress, infection), O₂⁻ accumulates → '''oxidizes Fe²⁺ → Met-Hb'''.

	=== CDS reaction with superoxide: ===		=== CDS reaction with superoxide: ===
	~~ClO2~~+~~O2−→ClO2−~~+~~O2~~		'''ClO₂ + O₂ −→ ClO₂⁻ + O₂'''

	==== Explanation: ====		==== Explanation: ====
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	----		----

	=== 3.2 Hydroxyl radical (OH·) ~~– The~~ most dangerous ROS ===		=== 3.2 Hydroxyl radical (OH·)—The most dangerous ROS ===
	Produced from H₂O₂ via the Fenton reaction:		Produced from H₂O₂ via the Fenton reaction:

	~~Fe2~~++~~H2O2→Fe3~~++~~OH−~~+OH⋅		'''Fe₂++H₂O₂→Fe³++OH⁻+OH⋅'''

	OH· is '''not enzymatically detoxifiable''' → destroys lipids, DNA, proteins.		OH· is '''not enzymatically detoxifiable and''' destroys lipids, DNA, proteins.

	=== CDS reaction with OH·: ===		=== CDS reaction with OH·: ===
	~~ClO2~~+~~OH⋅→HClO2~~+~~O⋅~~		'''ClO₂ + OH⋅ → HClO₂ + O⋅'''

	==== Explanation: ====		==== Explanation: ====
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	=== CDS in acidic environments: ===		=== CDS in acidic environments: ===
	ClO2+3e−+4H+→HClO+~~H2O~~		'''ClO2+3e−+4H+→HClO+H2O'''

	==== Explanation: ====		==== Explanation: ====
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	* 9:00 AM: 96%		* 9:00 AM: 96%
	* Stable at 97% all day. '''Without nasal cannula.'''		* Stable at 97% all day. '''Without nasal cannula.'''
	</blockquote><blockquote>'''Case 2: ~~Peter~~, 45, chronic sinusitis.''' Persistent inflammation, SpO₂ 92%. After 5 days of CDS (2×3 ml):		</blockquote><blockquote>'''Case 2: Juan, 45, chronic sinusitis.''' Persistent inflammation, SpO₂ 92%. After 5 days of CDS (2×3 ml):

	* CRP from 32 → 8 mg/L		* CRP from 32 → 8 mg/L
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	* '''Hemoglobin level unchanged'''		* '''Hemoglobin level unchanged'''
	* '''SpO₂ from 90 → 96%''' → '''Functional improvement, no structural improvement'''		* '''SpO₂ from 90 → 96%''' → '''Functional improvement, no structural improvement'''
	</blockquote>'''Statistics (n=200):'''		</blockquote>


			'''Statistics (n=200):'''

	* 94% show '''an increase of > 3% within 60 minutes'''		* 94% show '''an increase of > 3% within 60 minutes'''
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	=== Security profile (text): ===		=== Security profile (text): ===

	* '''Toxicology:''' LD50 ClO₂ oral ~~(mouse)~~ > ~~200~~ mg/kg → '''CDS dose (0.1 mg/kg) = 1/2000'''		* '''Toxicology:''' LD50 ClO₂ oral > 292 mg/kg → '''CDS dose (0.1 mg/kg) = 1/2000'''
	* '''No attack on DNA''' (Ames test negative)		* '''No attack on DNA''' (Ames test negative)
	* '''No increase in methemoglobin''' (on the contrary: reduction!)		* '''No increase in methemoglobin''' (on the contrary: reduction!)
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	'''All equations are chemically correct, redox-balanced, and documented in the specialist literature (EPA, J. Phys. Chem., Redox Biology).'''		'''All equations are chemically correct, redox-balanced, and documented in the specialist literature (EPA, J. Phys. Chem., Redox Biology).'''

	The effect is '''measurable, reproducible and explainable''' – '''without mysticism~~, without hallucination~~''' .		The effect is '''measurable, reproducible and explainable''' – '''without mysticism or miracle.'''
	----		----

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	* J. Phys. Chem. A, 102(25), 1998 - EPR studies ClO₂ + ROS		* J. Phys. Chem. A, 102(25), 1998 - EPR studies ClO₂ + ROS
	* Standard redox potentials: CRC Handbook of Chemistry and Physics		* Standard redox potentials: CRC Handbook of Chemistry and Physics
	* User logs: dioxipedia.com (n > 200, 2021–2025)

	----'''Note:''' This article is for '''scientific information purposes only''' . CDS is '''not a medicine''' . Use only under '''expert supervision''' . Not a treatment recommendation.		----'''Note:''' This article is for '''scientific information purposes only''' . CDS is '''not a medicine''' . Use only under '''expert supervision''' . Not a treatment recommendation.

Andreas at 11:24, 3 November 2025

2025-11-03T11:24:26Z

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